GLP-1 Market
LLY $1123.00 ▼ -0.1% NVO $44.01 ▼ -1.2% PFE $27.65 ▼ -0.5% VKTX $32.13 ▼ -1.7% KLRA $14.91 ▲ +0.5% GPCR $39.55 ▼ -4.1% RHHBY $53.19 ▼ -0.4% HIMS $27.44 ▼ -1.6% WW $14.78 ▼ -1.1%
Delayed · As of 9:20 AM
About this data Sourced primarily from ClinicalTrials.gov — a listing isn't proof of safety or FDA approval.

Pipeline and clinical trial information here comes primarily from ClinicalTrials.gov. A listing on ClinicalTrials.gov means a study has been registered — not that a treatment is proven safe, effective, or FDA-approved. Investigational treatments may never be approved. Who can join a trial is decided only by that trial's own study team.

Approved

Semaglutide

Company
Novo Nordisk
Mechanism
mono GLP-1
Route
Oral & injectable
Recruiting trials
156 recruiting
12.4% Placebo-adjusted weight loss · 68 weeks · Adults with obesity or overweight, without type 2 diabetes · STEP 1
Find a Clinical Trial Near Me

156 recruiting studies currently listed on ClinicalTrials.gov.

Data source: ClinicalTrials.gov · trial data as of Sep 11, 2026

Find a Clinical Trial Near Me

See recruiting studies for Semaglutide and check eligibility with the study team.

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Treatment type

"Added to GLP-1" means the investigational treatment is being studied on top of an existing GLP-1-based therapy.

Your ZIP code is only used to calculate distance to trial sites — it isn't stored.

Trial details
  • Recruiting NCT NCT03884075

    Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)

    Not yet reported National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 104 participants Est. completion 2027-12-31 1 site Stand-alone
    Other conditions: Non-Alcoholic Steatohepatitis, Non-Alcoholic Fatty Liver Disease
    View official trial listing →
  • Recruiting NCT NCT04174755

    Semaglutide's Efficacy in Achieving Weight Loss for Those With HIV

    Not yet reported University College Dublin 80 participants Est. completion 2027-07 1 site
    Other conditions: Obesity, HIV-1-infection
    View official trial listing →
  • Recruiting NCT NCT04873050

    Treatment to Regress to Normoglycemia in Women with a Recent History of GDM

    Not yet reported Woman's 102 participants Est. completion 2026-03-01 1 site
    Other conditions: Pre Diabetes, Postpartum Disorder
    View official trial listing →
  • Recruiting NCT NCT05071898

    Pharmacogenetics of Response to GLP1R Agonists

    Not yet reported University of Maryland, Baltimore 600 participants Est. completion 2028-04 1 site Stand-alone
    Other conditions: Obesity, Diabetes Type 2
    View official trial listing →
  • Recruiting NCT NCT05119179

    Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes

    Not yet reported The University of Texas Health Science Center, Houston 300 participants Est. completion 2026-10-31 1 site
    Prediabetes
    View official trial listing →
  • Recruiting NCT NCT05173714

    Sit Less, Interact and Move More (SLIMM) 2 Study

    Not yet reported Srinvasan Beddhu 156 participants Est. completion 2027-03-31 2 sites Stand-alone
    Chronic kidney disease Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT05305794

    Effect of Weekly GLP1 Agonist Treatment in "Double Diabetes"

    Not yet reported Centre Hospitalier Universitaire Dijon 76 participants Est. completion 2028-08 1 site Stand-alone
    Other conditions: Double Diabetes
    View official trial listing →
  • Recruiting NCT NCT05340868

    Genetics of the Acute Response to Oral Semaglutide

    Not yet reported Medical University of Bialystok 1000 participants Est. completion 2025-12-31 1 site Stand-alone
    Prediabetes Other conditions: Prediabetic State, Obesity
    View official trial listing →
  • Recruiting NCT NCT05356104

    GLP-1 Analogue in Preventing Progression of Small Vessel Disease (GAPP-SVD)

    Not yet reported Chinese University of Hong Kong 110 participants Est. completion 2027-12 2 sites
    Other conditions: Cerebral Small Vessel Disease
    View official trial listing →
  • Recruiting NCT NCT05419726

    Brown Adipose Tissue Activity in Response to Semaglutide Administered to Obese Subjects.

    University of California, Los Angeles 20 participants Est. completion 2026-02-01 1 site
    Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT05424003

    Randomized Double Blinded Placebo-Controlled w/Semaglutide to Prevent Weight Gain After Liver Transplant

    Not yet reported University of Virginia 50 participants Est. completion 2026-08-01 1 site Stand-alone
    MASLD
    View official trial listing →
  • Recruiting NCT NCT05501483

    Adipose Tissue Heterogeneity and Its Link to Type 2 Diabetes

    Not yet reported Karolinska Institutet 60 participants Est. completion 2032-12-31 1 site
    Type 2 diabetes
    View official trial listing →
  • Recruiting NCT NCT05569772

    Semaglutide for the Treatment of Glucose Intolerance in Women With Prior Gestational Diabetes

    Not yet reported Universitaire Ziekenhuizen KU Leuven 252 participants Est. completion 2029-12 13 sites
    Other conditions: Glucose Intolerance After a Recent History of Gestational Diabetes
    View official trial listing →
  • Recruiting NCT NCT05586802

    Sex Steroids Balance for Metabolic and Reproductive Health in Klinefelter Syndrome

    Not yet reported Georgios Papadakis 150 participants Est. completion 2027-04-30 1 site Stand-alone
    Other conditions: Klinefelter Syndrome
    View official trial listing →
  • Recruiting NCT NCT05630586

    Acute Subcutaneous SemaglutidE in Acute Ischemic sTroke

    Not yet reported Aarhus University Hospital 380 participants Est. completion 2027-12 1 site
    Cardiovascular disease
    View official trial listing →
  • Recruiting NCT NCT05700877

    Screening and Intervention for Subclinical Coronary Artery Disease in Patients With Type 2 Diabetes

    Not yet reported Per Løgstrup Poulsen 7300 participants Est. completion 2029-03-01 1 site
    Type 2 diabetesCardiovascular disease
    View official trial listing →
  • Recruiting NCT NCT05702931

    Semaglutide Treatment for Hyperglycaemia After Renal Transplantation

    Not yet reported Rigshospitalet, Denmark 104 participants Est. completion 2027-12 1 site
    Other conditions: Hyperglycemia, Renal Transplant Complication Primary Non-Function, Diabetes
    View official trial listing →
  • Recruiting NCT NCT05746039

    Feasibility of Semaglutide in Advanced Lung Disease

    Not yet reported, Not yet reported University of Pennsylvania 8 participants Est. completion 2027-12-28 1 site Stand-alone
    Other conditions: Obesity, Interstitial Lung Disease, Chronic Obstructive Pulmonary Disease, Sarcoidosis, Pulmonary, Pulmonary Hypertension
    View official trial listing →
  • Recruiting NCT NCT05780905

    Effects of Semaglutide on Intracranial Blood Flow and Brain-Barrier Permeability in Type-2 Diabetes

    Not yet reported University of Washington 50 participants Est. completion 2026-12-31 1 site
    Type 2 diabetesCardiovascular disease
    View official trial listing →
  • Recruiting NCT NCT05819138

    Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes

    Not yet reported University of Colorado, Denver 60 participants Est. completion 2027-12-01 2 sites Stand-alone
    Other conditions: Diabetes Mellitus, Type 1
    View official trial listing →
  • Recruiting NCT NCT05819853

    Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome

    Not yet reported University of Colorado, Denver 80 participants Est. completion 2028-06-30 1 site
    Other conditions: PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Obese
    View official trial listing →
  • Recruiting NCT NCT05822609

    Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes

    Not yet reported University of Washington 60 participants Est. completion 2027-12 4 sites Stand-alone
    Chronic kidney disease Other conditions: Type 1 Diabetes
    View official trial listing →
  • Recruiting NCT NCT05925959

    Preoperative Weight Loss for Open Abdominal Wall Reconstruction

    Not yet reported Benjamin T. Miller 258 participants Est. completion 2027-06-01 2 sites
    Other conditions: Abdominal Wall Hernia
    View official trial listing →
  • Recruiting NCT NCT05938712

    The Efficacy, Mechanism & Safety of Sodium Glucose Co-Transporter-2 Inhibitor & Glucagon-Like Peptide 1 Receptor Agonist Combination Therapy in Kidney Transplant Recipients

    Not yet reported University Health Network, Toronto 20 participants Est. completion 2028-03-01 1 site
    Other conditions: Kidney Transplant Recipients
    View official trial listing →
  • Recruiting NCT NCT06003153

    GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGH

    Not yet reported Massachusetts General Hospital 125 participants Est. completion 2027-05-31 1 site
    Type 2 diabetes Other conditions: Genetic Predisposition, Metabolic Diseases
    View official trial listing →
  • Recruiting NCT NCT06060392

    Effect of Oral Semaglutide on Liver Fat and Body Composition in Liver Transplant Recipients With Diabetes Mellitus

    Not yet reported Medanta, The Medicity, India 50 participants Est. completion 2025-11-01 1 site Stand-alone
    Other conditions: Liver Transplant; Complications, Diabete Mellitus
    View official trial listing →
  • Recruiting NCT NCT06069622

    Role of Caveolin 1 (CAV-1) Deficiency in Response to Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Treatment

    Brigham and Women's Hospital 30 participants Est. completion 2026-11-30 1 site
    Other conditions: Overweight and Obesity
    View official trial listing →
  • Recruiting NCT NCT06072963

    COMMETS- Combination MCI Metabolic Syndrome

    Not yet reported Rutgers, The State University of New Jersey 80 participants Est. completion 2028-12-01 1 site Stand-alone
    Metabolic syndrome Other conditions: Alzheimer Disease, Mild Cognitive Impairment
    View official trial listing →
  • Recruiting NCT NCT06082063

    Multifactorial Intervention to Reduce Cardiovascular Disease in Type 1 Diabetes

    Not yet reported Steno Diabetes Center Copenhagen 2000 participants Est. completion 2029-07-01 2 sites
    Cardiovascular diseaseHeart failure Other conditions: Type 1 Diabetes, Kidney Failure
    View official trial listing →
  • Recruiting NCT NCT06173778

    Semaglutide for Post-Smoking Cessation Weight Management

    Not yet reported The University of Texas Health Science Center, Houston 197 participants Est. completion 2026-08-01 2 sites Stand-alone
    Other conditions: Obesity, Overweight, Cigarette Smoking
    View official trial listing →
  • Recruiting NCT NCT06184633

    DUTCH Weight Control in Atrial Fibrillation Study

    Not yet reported Rijnstate Hospital 280 participants Est. completion 2027-05-01 1 site
    Other conditions: Atrial Fibrillation, Obesity, Weight Loss
    View official trial listing →
  • Recruiting NCT NCT06271200

    Strategic Lifestyle Intervention for Metabolic Syndrome (SLIM-MET)

    Not yet reported National Health Research Institutes, Taiwan 200 participants Est. completion 2027-12-31 1 site Stand-alone
    Metabolic syndrome
    View official trial listing →
  • Recruiting NCT NCT06318442

    The GAPSID Study - How GLP-1 Analogues Prevent Steroid-Induced Diabetes

    Not yet reported Imperial College London 60 participants Est. completion 2027-06-01 1 site Stand-alone
    Other conditions: Steroid-Induced Diabetes, Steroid Induced Hyperglycemia
    View official trial listing →
  • Recruiting NCT NCT06338553

    GLP-1Ra Impact on Metabolic Outcomes in Stage 2 T1DM While Receiving Teplizumab

    Not yet reported Vanderbilt University Medical Center 24 participants Est. completion 2027-03 1 site Stand-alone
    Other conditions: Type 1 Diabetes
    View official trial listing →
  • Recruiting NCT NCT06374875

    Fibrosis Lessens After Metabolic Surgery

    Not yet reported The Cleveland Clinic 120 participants Est. completion 2029-12-31 22 sites
    MASLDMASH Other conditions: Non-Alcoholic Fatty Liver Disease, Liver Fibrosis, Obesity
    View official trial listing →
  • Recruiting NCT NCT06380426

    A Multicenter Pharmacoepidemiological Cohort on Real Life Use of Semaglutide in Adolescents or Adults With Monogenic Obesity

    Assistance Publique - Hôpitaux de Paris 175 participants Est. completion 2027-11-30 2 sites
    Other conditions: Monogenic Obesity
    View official trial listing →
  • Recruiting NCT NCT06387199

    Alleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous Semaglutide

    Not yet reported, Not yet reported McGill University Health Centre/Research Institute of the McGill University Health Centre 26 participants Est. completion 2027-01 1 site Stand-alone
    Other conditions: Type 1 Diabetes, Diabetes Mellitus
    View official trial listing →
  • Recruiting NCT NCT06396416

    Obesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2

    Not yet reported Western University, Canada 60 participants Est. completion 2026-12 1 site Stand-alone
    Chronic kidney disease Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT06411210

    Obesity Complicating Type 1 Diabetes: GLP-1 Analogue Anti-obesity Treatment

    Not yet reported Yale University 54 participants Est. completion 2028-06-30 1 site
    Other conditions: Diabetes type1, Obesity
    View official trial listing →
  • Recruiting NCT NCT06423599

    Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart Failure

    Not yet reported, Not yet reported Jens D Hove, MD,PHD 100 participants Est. completion 2027-12-30 1 site Stand-alone
    Heart failure Other conditions: Obesity, Weight Loss
    View official trial listing →
  • Recruiting NCT NCT06431308

    Nutritional Therapy to Incretin-based Anti-obesity Medications in the Management of Gastrointestinal Adverse Events

    Not yet reported Ariel University 120 participants Est. completion 2026-03-30 3 sites
    Other conditions: Obesity; Drug
    View official trial listing →
  • Recruiting NCT NCT06446531

    Prevention of Progression of Prediabetes, Obesity and CV Risk

    Not yet reported The University of Texas Health Science Center at San Antonio 64 participants Est. completion 2027-07 1 site
    PrediabetesCardiovascular disease Other conditions: Weight, Body
    View official trial listing →
  • Recruiting NCT NCT06461377

    The Ameliorative Effects of GLP-1RA on Diabetic Cardiac Autonomatic Neuropathy

    Not yet reported The First Affiliated Hospital with Nanjing Medical University 50 participants Est. completion 2027-12-31 1 site
    Type 2 diabetes Other conditions: Diabetes With Diabetic Autonomic Neuropathy (Diagnosis)
    View official trial listing →
  • Recruiting NCT NCT06487832

    Effect of GLP1 Receptor Agonist on Brain Insulin Responsiveness

    Not yet reported University Hospital Tuebingen 60 participants Est. completion 2027-12-31 1 site Stand-alone
    Other conditions: Normal Weight, Overweight and Obesity, Insulin Sensitivity, Insulin Resistance
    View official trial listing →
  • Recruiting NCT NCT06497595

    Lifestyle Intervention to Reduce the Risk of Sarcopenia in Adults With Diabetes & Obesity Treated With Semaglutide

    Not yet reported Sheba Medical Center 60 participants Est. completion 2027-11-30 2 sites
    Type 2 diabetes
    View official trial listing →
  • Recruiting NCT NCT06499857

    Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation

    Not yet reported University of Chicago 200 participants Est. completion 2028-06 2 sites
    Other conditions: Overweight or Obesity, Atrial Fibrillation
    View official trial listing →
  • Recruiting NCT NCT06548490

    GLP-1R Agonist Treatment for Opioid Use Disorder

    Not yet reported Milton S. Hershey Medical Center 200 participants Est. completion 2027-04-30 4 sites
    Substance use disorder Other conditions: Opioid Abuse and Addiction, Narcotic-Related Disorders, Chemically-Induced Disorders, Mental Disorder, Opioid
    View official trial listing →
  • Recruiting NCT NCT06575738

    Physiologic Response to Bariatric Surgery and the Impact of Adjunct Semaglutide in Adolescents

    Not yet reported University of Colorado, Denver 40 participants Est. completion 2027-10-01 1 site
    Other conditions: Obesity, Adolescent Obesity, Body-Weight Trajectory, Weight Loss Trajectory, Bariatric Surgery, Anti-obesity Agents
    View official trial listing →
  • Recruiting NCT NCT06613854

    Effect of Early Combination Antihyperglycemic Treatment on Metabolic Control in Individuals With Type 2 Diabetes

    Not yet reported University Medical Centre Ljubljana 90 participants Est. completion 2027-12 1 site
    Type 2 diabetes
    View official trial listing →
  • Recruiting NCT NCT06639464

    Semaglutide for Helping Opioid Recovery

    Not yet reported Brigham and Women's Hospital 46 participants Est. completion 2026-08-31 1 site Stand-alone
    Substance use disorder
    View official trial listing →
  • Recruiting NCT NCT06686134

    Comprehensive Clinical Evaluation Study of GLP-1RA

    LI YAN 492 participants Est. completion 2026-07-31 1 site
    Type 2 diabetes
    View official trial listing →
  • Recruiting NCT NCT06706284

    Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord Injury and Type 2 Diabetes

    Not yet reported Marzieh Salehi 50 participants Est. completion 2029-03-01 2 sites Stand-alone
    Type 2 diabetes Other conditions: Spinal Cord Injuries
    View official trial listing →
  • Recruiting NCT NCT06717698

    A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease

    Not yet reported Novo Nordisk A/S 465 participants Est. completion 2026-09-17 147 sites
    Chronic kidney disease
    View official trial listing →
  • Recruiting NCT NCT06734312

    MAINTAIN (Mucosal AblatIoN Therapy After INcretins)

    Not yet reported Dr. Christopher McGowan 20 participants Est. completion 2026-06 2 sites
    Other conditions: Obesity and Obesity-related Medical Conditions, Obesity and Overweight, Obesity Prevention, Obesity Recidivism, GLP-1, Ablation Techniques
    View official trial listing →
  • Recruiting NCT NCT06751589

    A Study of a Weight Loss Intervention in People With Endometrial Cancer

    Not yet reported Memorial Sloan Kettering Cancer Center 36 participants Est. completion 2027-12 7 sites Added to GLP-1
    Other conditions: Endometrial Cancer
    View official trial listing →
  • Recruiting NCT NCT06790160

    Study of Patients Being Treated With Anti-obesity Medication

    Texas Tech University 100 participants Est. completion 2027-12 1 site
    Other conditions: Obesity and Overweight
    View official trial listing →
  • Recruiting NCT NCT06792422

    A Study Investigating Oral Semaglutide in People with Open-Angle Glaucoma

    Not yet reported Glostrup University Hospital, Copenhagen 126 participants Est. completion 2028-12 1 site Stand-alone
    Other conditions: Primary Open Angle Glaucoma (POAG), Open-Angle Glaucoma, Glaucoma
    View official trial listing →
  • Recruiting NCT NCT06821919

    Impact of Antiglycemic & Immunosuppressive Therapies on NETosis in Diabetes & Kidney Disease (NETs - Neutrophil Traps)

    Western Galilee Hospital-Nahariya 70 participants Est. completion 2031-12-30 1 site
    Other conditions: Diabetes Mellitus, Kidney Disease
    View official trial listing →
  • Recruiting NCT NCT06830343

    The Safety, Tolerability, and Pharmacokinetics of of SYH9017 in Chinese Participants With Overweight and Obesity

    Not yet reported CSPC Baike (Shandong) Biopharmaceutical Co., Ltd. 66 participants Est. completion 2026-10-01 1 site
    Other conditions: Overweight or Obesity
    View official trial listing →
  • Recruiting NCT NCT06852391

    JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity

    Not yet reported McMaster University 74 participants Est. completion 2027-12-31 1 site Stand-alone
    Other conditions: Obesity (Disorder)
    View official trial listing →
  • Recruiting NCT NCT06856291

    Response to Semaglutide in Non-diabetic Obese Patients With Varying Degrees of Insulin Resistance

    ETH Zurich 40 participants Est. completion 2026-08-31 1 site
    Other conditions: Obesity and Obesity-related Medical Conditions, Obesity and Overweight, Insulin Sensitivity/Resistance, Semaglutide
    View official trial listing →
  • Recruiting NCT NCT06885736

    LEAN Mass Preservation With Resistance Exercise and Protein During Semaglutide/Tirzepatide Therapy

    Not yet reported Dasman Diabetes Institute 232 participants Est. completion 2029-12-31 1 site
    Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT06894784

    A Clinical Trial to Evaluate The Effects of Semaglutide and Empagliflozin Combined to Automated Insulin Delivery on Diabetes Control in Adults Living With Type 1 Diabetes

    Not yet reported McGill University Health Centre/Research Institute of the McGill University Health Centre 36 participants Est. completion 2027-01 1 site Stand-alone
    Other conditions: Diabetes Type 1
    View official trial listing →
  • Recruiting NCT NCT06896981

    Semaglutide in Women With Polycystic Ovary Syndrome and Obesity

    Not yet reported, Not yet reported Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh 30 participants Est. completion 2025-12-31 1 site Stand-alone
    Other conditions: Polycystic Ovary Syndrome (PCOS) Women, Obesity
    View official trial listing →
  • Recruiting NCT NCT06897475

    A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide

    Not yet reported Eli Lilly and Company 240 participants Est. completion 2027-01 60 sites
    Type 2 diabetes
    View official trial listing →
  • Recruiting NCT NCT06903923

    Bone Metabolism in 12-21 Year Olds Undergoing Glucagon Like Peptide (GLP)-1 Receptor Agonist Therapy

    Not yet reported University of Virginia 120 participants Est. completion 2030-04-30 1 site
    Other conditions: Obesity in Children, Bone Strength, GLP - 1, Lifestyle Modification, Bone Density, Obesity
    View official trial listing →
  • Recruiting NCT NCT06908694

    Investigation of GLP1-Receptor Agonists in Men With Prostate Cancer Taking Androgen Deprivation Therapy

    Not yet reported Hamilton Health Sciences Corporation 20 participants Est. completion 2026-07-31 1 site
    Other conditions: Prostate Cancer
    View official trial listing →
  • Recruiting NCT NCT06934655

    Early Reinitiation of Semaglutide Post-Sleeve Gastrectomy in Youth

    Not yet reported Children's Hospital Los Angeles 150 participants Est. completion 2033-11-01 1 site
    Other conditions: Pediatric Obesity, Metabolic and Bariatric Surgery, Semaglutide
    View official trial listing →
  • Recruiting NCT NCT06937060

    Effect of Semaglutide in Patients With Psoriasis and Obesity

    Not yet reported The University of Hong Kong 14 participants Est. completion 2027-01-31 1 site
    Other conditions: Psoriasis (PsO), Obesity and Overweight
    View official trial listing →
  • Recruiting NCT NCT06967389

    Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity

    John Bauer 50 participants Est. completion 2028-07 1 site
    Cardiovascular disease Other conditions: Obesity and Overweight, Obese Adolescents, Weight Management, Weight Loss
    View official trial listing →
  • Recruiting NCT NCT06975111

    Focusing on the Menopausal Transition to Improve Mid-Life Women's Health

    Not yet reported, Not yet reported University of Colorado, Denver 200 participants Est. completion 2030-10-01 3 sites
    Other conditions: Menopause, Menopause Hot Flashes, Menopause Related Conditions, Cardiovascular
    View official trial listing →
  • Recruiting NCT NCT06986993

    Impact of Semaglutide on Tobacco Use and Related Health Behaviors

    Not yet reported University of Oklahoma 40 participants Est. completion 2028-06-30 1 site
    Other conditions: Tobacco Use
    View official trial listing →
  • Recruiting NCT NCT06989177

    Probiotic Intervention on Body Weight

    Not yet reported Chinese Academy of Sciences 140 participants Est. completion 2026-12-31 1 site
    Other conditions: Obesity, Homeostasis, Weight Loss, Probiotic Intervention
    View official trial listing →
  • Recruiting NCT NCT06989203

    Protein Supplementation Intervention on Body Weight

    Not yet reported Chinese Academy of Sciences 140 participants Est. completion 2026-12-31 1 site Stand-alone
    Other conditions: Obesity, Weight Loss, Protein Supplementation
    View official trial listing →
  • Recruiting NCT NCT07010432

    The Role of the Amylin Analogue Cagrilintide in Bone Metabolism

    Not yet reported Novo Nordisk A/S 144 participants Est. completion 2028-05-03 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT07036172

    Efficacy and Safety of Semaglutide Injection Vs WEGOVY® in Chinese Obese Patients

    Not yet reported Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. 460 participants Est. completion 2026-05 1 site
    Other conditions: Obesity Control
    View official trial listing →
  • Recruiting NCT NCT07040592

    Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 3 Semaglutide

    Not yet reported Yale University 30 participants Est. completion 2027-06-30 1 site Stand-alone
    Alcohol use disorder Other conditions: HIV
    View official trial listing →
  • Recruiting NCT NCT07042672

    Behavioral Therapy and GLP-1 Analogue Effects on Binge Eating, Weight, and Coping in Obesity

    Haukeland University Hospital 80 participants Est. completion 2028-12-31 1 site
    Other conditions: Binge Eating Disorder Associated With Obesity, Binge Eating Disorder, Eating Disorder Binge, Eating Disorders, GLP-1, CBT, Obesity &Amp; Overweight
    View official trial listing →
  • Recruiting NCT NCT07058155

    Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease

    Not yet reported The Cleveland Clinic 70 participants Est. completion 2034-02-01 1 site
    Other conditions: Liver Cirrhoses, Portal Hypertension Related to Cirrhosis, Severe Obesity, TIPS
    View official trial listing →
  • Recruiting NCT NCT07059377

    Semaglutide for Smoking Cessation in Patients With Diabetes

    Not yet reported Ottawa Heart Institute Research Corporation 100 participants Est. completion 2027-07 1 site
    Type 2 diabetes Other conditions: Nicotine Addiction, Tobacco Dependence
    View official trial listing →
  • Recruiting NCT NCT07064486

    A Study of BGM0504 in Participants With Type 2 Diabetes in Indonesia

    Not yet reported BrightGene Bio-Medical Technology Co., Ltd. 477 participants Est. completion 2026-07-31 4 sites
    Type 2 diabetes
    View official trial listing →
  • Recruiting NCT NCT07065383

    Rebalancing the Fat Content of the Heart and Muscles

    Not yet reported University of Aberdeen 60 participants Est. completion 2028-07-31 1 site
    Type 2 diabetes
    View official trial listing →
  • Recruiting NCT NCT07091500

    Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Therapy and Exercise Training in People With Obesity

    Not yet reported Washington University School of Medicine 40 participants Est. completion 2029-08-01 1 site Added to GLP-1
    Other conditions: Obesity, Skeletal Muscle, Brain Connectivity
    View official trial listing →
  • Recruiting NCT NCT07092618

    Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation

    Not yet reported, Not yet reported AgelessRx 150 participants Est. completion 2025-08 1 site Stand-alone
    Other conditions: Longevity, GLP-1, Geroscience, Aging
    View official trial listing →
  • Recruiting NCT NCT07101939

    A Study of the Effect of (S)-Pindolol Benzoate (ACM-001.1) on Lean Body Mass (LBM) in Obese Patents During (PROACT 1), and Post-semaglutide Therapy (PROACT 2)

    Not yet reported Actimed Therapeutics Ltd 120 participants Est. completion 2027-03 7 sites
    Other conditions: Obesity, Muscle Loss
    View official trial listing →
  • Recruiting NCT NCT07107334

    A Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients With Endometrioid Intraepithelial Neoplasia

    Not yet reported University of Florida 20 participants Est. completion 2029-11 1 site Stand-alone
    Other conditions: Endometrioid Endometrial Adenocarcinoma
    View official trial listing →
  • Recruiting NCT NCT07136714

    Does Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder and Overweight or Obesity

    Not yet reported Nordsjaellands Hospital 116 participants Est. completion 2027-09 1 site Stand-alone
    Other conditions: Major Depressive Disorder
    View official trial listing →
  • Recruiting NCT NCT07150975

    Phase III Clinical Study Comparing the Efficacy and Safety of GZR18 Injection and Semaglutide (Wegovy®) in Adult Obese or Overweight Subjects

    Not yet reported Gan & Lee Pharmaceuticals. 420 participants Est. completion 2027-06-30 1 site
    Other conditions: Obesity/Overweight in Adult
    View official trial listing →
  • Recruiting NCT NCT07169136

    Effects of Glucagon-like Peptide-1 (GLP-1) Agonist in Neuro-reproductive Function in Obese Adolescent Females With Polycystic Ovary Syndrome (PCOS)

    Nemours Children's Clinic 20 participants Est. completion 2026-12 1 site
    Other conditions: Polycystic Ovarian Syndrome in Adolescent Females, Obesity (Disorder)
    View official trial listing →
  • Recruiting NCT NCT07171723

    Studying the Influence of LEAP2 on Integrated Endocrine Control of Eating During Semaglutide Treatment

    Not yet reported, Not yet reported University Hospital, Gentofte, Copenhagen 24 participants Est. completion 2026-02-01 1 site Stand-alone
    Other conditions: Obesity &Amp; Overweight
    View official trial listing →
  • Recruiting NCT NCT07178145

    Epicardial Adipose Tissue Composition and Heart Failure With Preserved Ejection Fraction

    Not yet reported University of Virginia 192 participants Est. completion 2029-12 1 site
    Heart failure Other conditions: Epicardial Adipose Tissue
    View official trial listing →
  • Recruiting NCT NCT07195994

    A Clinical Trial to Examine the Efficacy and Safety of an Investigational Product With and Without Use of Semaglutide on Glycemic Response in Adults With Prediabetes or Type 2 Diabetes

    Not yet reported QuickSilver Scientific 90 participants Est. completion 2026-09 1 site
    Type 2 diabetesPrediabetes
    View official trial listing →
  • Recruiting NCT NCT07204249

    Glutide for Ending Methamphetamine

    Not yet reported San Francisco Department of Public Health 162 participants Est. completion 2030-02-15 1 site Stand-alone
    Other conditions: Methamphetamine-dependence
    View official trial listing →
  • Recruiting NCT NCT07207148

    People With Multiple Sclerosis Treated With Ocrelizumab and GLP-1 Agonists

    Northwestern University 100 participants Est. completion 2028-08-31 1 site
    Other conditions: Multiple Sclerosis
    View official trial listing →
  • Recruiting NCT NCT07213323

    Probiotic Intervention for Digestive Health in Obese Patients Initiating GLP-RA Treatment

    Not yet reported Hospices Civils de Lyon 50 participants Est. completion 2028-08-05 1 site Stand-alone
    Other conditions: Obesity &Amp; Overweight, Digestive Disorders
    View official trial listing →
  • Recruiting NCT NCT07213466

    Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder

    Not yet reported Mayo Clinic 100 participants Est. completion 2029-02-01 1 site Stand-alone
    Other conditions: Bipolar I Disorder, Bipolar II Disorder, Schizo Affective Disorder, Obesity, Weight Loss, GLP - 1
    View official trial listing →
  • Recruiting NCT NCT07218354

    Cessation or Reduction of Alcohol Consumption in Veterans: A Randomized Controlled Trial for Alcohol Use Disorder (CRAVE)

    Not yet reported VA Office of Research and Development 622 participants Est. completion 2030-03-30 19 sites Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Recruiting NCT NCT07221214

    GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV

    Not yet reported Vanderbilt University Medical Center 200 participants Est. completion 2030-01-31 1 site
    Cardiovascular disease Other conditions: HIV, Alcohol, Smoking Cigarette
    View official trial listing →
  • Recruiting NCT NCT07223242

    Tailored Exercise Training Study Among Adults With HFpEF

    Not yet reported, Not yet reported University of Texas Southwestern Medical Center 120 participants Est. completion 2026-12-30 1 site Stand-alone
    Heart failure Other conditions: Diabetic Cardiomyopathies
    View official trial listing →
  • Recruiting NCT NCT07223983

    Semaglutide (SEMA) for Alcohol Use Disorder (AUD) After Metabolic and Bariatric Surgery (MBS)

    Not yet reported Yale University 10 participants Est. completion 2026-10-31 1 site
    Alcohol use disorder Other conditions: Weight Loss, Bariatric Surgery Patients
    View official trial listing →
  • Recruiting NCT NCT07225816

    Examination of How the Duration of Fasting and Temporary Stopping of GLP-1 Medications Affect the Amount of Food Left in the Stomach in People Using Liraglutide (Injected), Semaglutide (Taken by Mouth) or Semaglutide (Injected)

    Not yet reported Novo Nordisk A/S 71 participants Est. completion 2027-01-06 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT07229170

    Changes in Taste and Eating Habits Associated With GLP-1 Agonists in Weight Loss Patients

    San Raffaele Telematic University 150 participants Est. completion 2028-01-01 4 sites Stand-alone
    Other conditions: Obesity & Overweight, Taste Alterations, Weight Loss, Eating Behavior Changes
    View official trial listing →
  • Recruiting NCT NCT07239570

    A Biomarker-targeted Clinical Trial to Optimize Treatment for Patients With Chronic Kidney Disease

    Not yet reported Peter Rossing 125 participants Est. completion 2028-06 4 sites Stand-alone
    Chronic kidney disease
    View official trial listing →
  • Recruiting NCT NCT07242534

    Effect of Semaglutide on Embryo Quality in Overweight and Obese Patients Undergoing In Vitro Fertilization.

    Not yet reported Fundacion Dexeus 62 participants Est. completion 2027-05 5 sites Stand-alone
    Other conditions: Infertility, Obesity
    View official trial listing →
  • Recruiting NCT NCT07253285

    A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight

    Not yet reported Novo Nordisk A/S 460 participants Est. completion 2033-09-20 121 sites
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Recruiting NCT NCT07254572

    Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetes

    Not yet reported National Institute of Cardiology, Warsaw, Poland 300 participants Est. completion 2029-08-01 1 site Stand-alone
    Cardiovascular diseasePrediabetes
    View official trial listing →
  • Recruiting NCT NCT07254715

    Effect of Itopride on Semaglutide Gastroparesis

    Not yet reported Ain Shams University 60 participants Est. completion 2026-04 1 site
    Other conditions: Semaglutide-Induced Gastric Motility, Anesthesia
    View official trial listing →
  • Recruiting NCT NCT07272343

    The Impact of Semaglutide Compared to Energy Restriction on Type 2 Diabetes

    Not yet reported Second Affiliated Hospital of Nanchang University 100 participants Est. completion 2026-07-01 1 site
    Type 2 diabetes Other conditions: Semaglutide, Caloric Restriction
    View official trial listing →
  • Recruiting NCT NCT07272837

    Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass

    University of Alberta 50 participants Est. completion 2028-04-30 1 site
    Type 2 diabetes Other conditions: Obesity, Semaglutide, GLP-1, Diabetes
    View official trial listing →
  • Recruiting NCT NCT07275697

    Waiting on Atrial Fibrillation Intervention Therapy (WAIT) Study

    Not yet reported Emma Svennberg 200 participants Est. completion 2028-12-30 1 site
    Other conditions: Atrial Fibrillation (AF), Obesity & Overweight
    View official trial listing →
  • Recruiting NCT NCT07282613

    A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 80 participants Est. completion 2030-03-30 58 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Recruiting NCT NCT07284979

    Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes

    Not yet reported Kailera 1200 participants Est. completion 2028-04 59 sites
    Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT07293325

    Semaglutide and Tirzepatide for Genetic Aging Delay in Adults With Obesity

    Not yet reported Second Affiliated Hospital, Zhejiang University, School of Medicine 66 participants Est. completion 2027-06-02 1 site Stand-alone
    Other conditions: Adults With Simple Obesity
    View official trial listing →
  • Recruiting NCT NCT07294950

    Impact of Semaglutide Withdrawal on Cardiometabolic Profile and Physiology of Energy Balance: Recovery Effects After Semaglutide Termination

    Not yet reported Mount Sinai Hospital, Canada 98 participants Est. completion 2029-05 1 site
    Other conditions: Obesity (Disorder), Weight Change, Blood Pressure Monitoring, Appetite Regulation
    View official trial listing →
  • Recruiting NCT NCT07295223

    Effect of Glp-1 and Antidiabetic sgLT2 Agents for myoCardial infarcTion and Ultrasensitive Inflammatory Surveillance (GALACTUS Trial)

    Not yet reported Instituto Mexicano del Seguro Social 44 participants Est. completion 2026-09 1 site
    Cardiovascular disease
    View official trial listing →
  • Recruiting NCT NCT07297589

    Epicardial Cardiac Fat-CT (EPIC-CT)

    Not yet reported Instituto Mexicano del Seguro Social 136 participants Est. completion 2027-03 1 site
    Cardiovascular disease Other conditions: Epicardial Fat
    View official trial listing →
  • Recruiting NCT NCT07302802

    Efficacy of Semaglutide s.c. Once-weekly on Weight Loss and Management in Adolescents With Monogenic Obesity in Clinical Practice

    Prof. Dr. Martin Wabitsch 70 participants Est. completion 2028-12 7 sites
    Other conditions: Monogenic Obesity
    View official trial listing →
  • Recruiting NCT NCT07309094

    Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKD

    Cardenal Herrera University 250 participants Est. completion 2028-12-31 1 site
    Chronic kidney diseaseType 2 diabetes Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT07314684

    GLP1-RAs Effects on Inflammatory and Endothelial Biomarkers in T2DM

    Not yet reported Federico II University 80 participants Est. completion 2027-03-08 2 sites
    Type 2 diabetes
    View official trial listing →
  • Recruiting NCT NCT07317115

    Side-to-Side Duodeno-ileostomy Versus Semaglutide in Adults With Obesity and Type 2 Diabetes

    Not yet reported GT Metabolic Solutions, Inc. 20 participants Est. completion 2028-06 1 site
    Type 2 diabetes Other conditions: Obesity (Disorder), Obesity & Overweight
    View official trial listing →
  • Recruiting NCT NCT07325500

    Incretin Microdosing for Cardiometabolic Health in People With HIV

    Not yet reported The University of Texas Health Science Center, Houston 30 participants Est. completion 2029-06-30 1 site Stand-alone
    Other conditions: Weight Gain
    View official trial listing →
  • Recruiting NCT NCT07336862

    Bariatric Surgery Combined With GLP-1 Receptor Agonists Study

    Not yet reported, Not yet reported China-Japan Friendship Hospital 200 participants Est. completion 2027-12 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT07361874

    IMPACT-MACS: Adrenalectomy vs Semaglutide for Metabolic Outcomes in Mild Autonomous Cortisol Secretion

    Not yet reported University of Texas Southwestern Medical Center 75 participants Est. completion 2030-05-31 1 site
    Other conditions: Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS), Subclinical Cushing's, Mild Autonomous Cortisol Excess
    View official trial listing →
  • Recruiting NCT NCT07374328

    Triple Hypoglycemic Regimens In Patients With Newly Diagnosed Type 2 Diabetes Mellitus

    Not yet reported, Not yet reported Second Affiliated Hospital of Guangzhou Medical University 240 participants Est. completion 2026-08-31 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Recruiting NCT NCT07401992

    Effects of Semaglutide on Clinical Outcomes and Metabolic Inflammation in Psoriasis

    Not yet reported Hospital Universitario Dr. Jose E. Gonzalez 62 participants Est. completion 2027-02-28 1 site
    Other conditions: Psoriasis (PsO), Obesity & Overweight, Diabetes Mellitus - Type 2
    View official trial listing →
  • Recruiting NCT NCT07415954

    A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 270 participants Est. completion 2027-10-01 63 sites
    Type 2 diabetes
    View official trial listing →
  • Recruiting NCT NCT07428746

    Investigating the Impact of GLP-1 RA Therapy on Osteosarcopenia in Older Female Adults With Diabetes

    Not yet reported Emory University 20 participants Est. completion 2028-11 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Recruiting NCT NCT07446439

    A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use

    Not yet reported Vanda Pharmaceuticals 280 participants Est. completion 2026-12-01 10 sites
    Other conditions: Nausea and Vomiting, Obesity
    View official trial listing →
  • Recruiting NCT NCT07465965

    A Clinical Study of Semaglutide Nasal Spray in Overweight or Obese Adults

    Not yet reported Shanghai World Leader Pharmaceutical Co., Ltd. 60 participants Est. completion 2026-08-30 1 site Stand-alone
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Recruiting NCT NCT07502508

    Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Mellitus Who Are Not Achieving Glycemic Targets While Using GLP-1-Based Therapy

    Not yet reported Biomea Fusion Inc. 60 participants Est. completion 2027-07 17 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Recruiting NCT NCT07513168

    Low-Dose Semaglutide for Weight Loss in Obese Non-Diabetic Pakistani Adults

    Not yet reported Asian Institute Of Medical Sciences 60 participants Est. completion 2026-12-01 1 site Stand-alone
    Other conditions: Obesity, Weight Reduction, Cardiometabolic Risk Factors
    View official trial listing →
  • Recruiting NCT NCT07527195

    Understanding the Effect of CagriSema, Cagrilintide, and Semaglutide on Muscle Health (Role of Amylin Signature in Muscle Health)

    Not yet reported Novo Nordisk A/S 100 participants Est. completion 2028-06-09 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT07539415

    A Phase 1 Clinical Trial to Assess the Safety of DWRX5003 and Relative Bioavailability to DWC202502 and DWC202503 in Healthy Adult Volunteers

    Not yet reported Daewoong Pharmaceutical Co. LTD. 72 participants Est. completion 2026-11-17 1 site
    Type 2 diabetes Other conditions: Obesity & Overweight
    View official trial listing →
  • Recruiting NCT NCT07558863

    Effect of GLP-1RA on Cardiac Autonomic Neuropathy in Type 2 Diabetes

    Not yet reported The First Affiliated Hospital with Nanjing Medical University 60 participants Est. completion 2028-08-30 1 site
    Type 2 diabetes Other conditions: Diabetes With Diabetic Autonomic Neuropathy (Diagnosis)
    View official trial listing →
  • Recruiting NCT NCT07563699

    Safety, Tolerability and Efficacy of Semaglutide Depot in Subjects With Type-2 Diabetes Mellitus

    Not yet reported, Not yet reported Mapi Pharma Ltd. 24 participants Est. completion 2028-06 1 site
    Other conditions: Diabete Type 2
    View official trial listing →
  • Recruiting NCT NCT07564414

    A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight

    Not yet reported Novo Nordisk A/S 2500 participants Est. completion 2028-04-19 303 sites Stand-alone
    Type 2 diabetes Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT07581145

    Effect of Semaglutide on Healing of Foot Ulcers in Type 2 Diabetes Patients

    Not yet reported Ole Lander Svendsen 52 participants Est. completion 2029-12 1 site
    Type 2 diabetes
    View official trial listing →
  • Recruiting NCT NCT07589322

    Comparative Observation of Metabolic and Pharmacologic Adipose Remodeling With Enhanced Incretin AgonisTs

    Not yet reported Tri-Service General Hospital (TSGH) 120 participants Est. completion 2029-09-30 1 site
    Metabolic syndrome
    View official trial listing →
  • Recruiting NCT NCT07597018

    A Research Study to Compare Blood Levels of Cagrilintide After Multiple Doses of Different Versions of Cagrilintide in Adults With Overweight or Obesity

    Not yet reported Novo Nordisk A/S 234 participants Est. completion 2027-06-01 1 site Stand-alone
    Other conditions: Obesity, Overweight
    View official trial listing →
  • Recruiting NCT NCT07605572

    Impact of GLP-1 Receptor Agonists on Dry Eye Disease in Patients With Type 2 Diabetes Mellitus and Obesity

    Attikon Hospital 100 participants Est. completion 2027-02-28 1 site
    Other conditions: Dry Eye Disease (DED), Diabete Mellitus, GLP-1, Ocular Surface, Diabetes Type 2, Cornea
    View official trial listing →
  • Recruiting NCT NCT07621419

    Study of Adult Patients Residing in Argentina Diagnosed With Type 2 Diabetes Treated With a New Formulation of Semaglutide, Both Oral and Subcutaneous, in a Real-world Setting at 3 Months, 6 Months, and 1 Year of Follow-up, Quantifying the Reduction in Glycated Hemoglobin

    Hospital Italiano de Buenos Aires 145 participants Est. completion 2028-12-31 2 sites
    Other conditions: Diabetes Mellitus
    View official trial listing →
  • Recruiting NCT NCT07633639

    GLP-1 Therapy After Bariatric Surgery in Chinese Patients With Obesity

    Not yet reported China-Japan Friendship Hospital 200 participants Est. completion 2028-05-01 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT07639021

    A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity

    Not yet reported Novo Nordisk A/S 230 participants Est. completion 2027-07-12 25 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT07651319

    Interleukine-2 (IL-2) Plus Semaglutide in Alzheimer's Disease

    Not yet reported, Not yet reported The Methodist Hospital Research Institute 30 participants Est. completion 2029-12 1 site
    Other conditions: Alzheimer Dementia (AD)
    View official trial listing →
  • Recruiting NCT NCT07653412

    Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists.

    National and Kapodistrian University of Athens 220 participants Est. completion 2027-06-30 1 site
    Other conditions: Obesity (Disorder), Anti-obesity Agents, Precision Medicine
    View official trial listing →
  • Recruiting NCT NCT07662213

    A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus

    Not yet reported AstraZeneca 1200 participants Est. completion 2028-05-23 209 sites
    Type 2 diabetes
    View official trial listing →
  • Recruiting NCT NCT07702461

    Determination of Resistance Training Status for Patients on Glucagon-Like Peptide-1 Receptor Agonists

    Ohio State University 300 participants Est. completion 2027-01 1 site
    Other conditions: Obesity & Overweight, Diabetes (DM)
    View official trial listing →
  • Recruiting NCT NCT07720414

    Effects of GLP-1 RAs on Human Lactation Outcomes

    University of Colorado, Denver 18 participants Est. completion 2028-06 1 site
    Other conditions: Lactation, Weight Loss
    View official trial listing →
  • Recruiting NCT NCT07728669

    Digital Dietary Intervention for Patients Receiving GLP-1 Receptor Agonist Therapy

    Not yet reported Kazakh Academy of Nutrition 120 participants Est. completion 2027-01 1 site
    Type 2 diabetesMetabolic syndrome Other conditions: Obesity (Disorder), Overweight
    View official trial listing →
  • Recruiting NCT NCT07732426

    Effects of Semaglutide on Brain Dopamine Responses to Food Cues in Adults With Obesity and Food Addiction Tendencies

    Not yet reported Seoul National University Hospital 30 participants Est. completion 2028-06-30 1 site Stand-alone
    Other conditions: Food Addiction Tendency, Obesity, Overweight
    View official trial listing →
  • Recruiting NCT NCT07740291

    Tirzepatide Impact Assessment Study

    Not yet reported Texas Tech University 27 participants Est. completion 2026-12-07 1 site
    Other conditions: Obesity & Overweight, Cardiometabolic Health Indicators, Addiction, Eating Disorders, Mental Health
    View official trial listing →
  • Recruiting NCT NCT07743983

    A Study of BGM0504 in Early T2DM With Obesity

    Not yet reported BrightGene Bio-Medical Technology Co., Ltd. 372 participants Est. completion 2028-11-30 1 site
    Type 2 diabetes
    View official trial listing →
  • Recruiting NCT NCT07767175

    A First-in-human Research Study on How NNC0721-8060 Works in People Living With Overweight or Obesity

    Not yet reported Novo Nordisk A/S 142 participants Est. completion 2027-09-23 2 sites
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Recruiting NCT NCT07770841

    Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight

    Not yet reported Novo Nordisk A/S 450 participants Est. completion 2028-04-11 62 sites Stand-alone
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Recruiting NCT NCT07779343

    OBESIAL: A Prospective Interventional Real-world Study of a Multidisciplinary Obesity Management Programme

    Not yet reported University of Health Sciences, Algeria 300 participants Est. completion 2028-01-23 1 site Stand-alone
    Type 2 diabetes Other conditions: Obesity Difficult Airway Airway Management, Obesity Adult Onset, Obesity and Cardiovascular Risk
    View official trial listing →
  • Recruiting NCT NCT07801820

    Phase 2 Clinical Study of MWN109 Tablets in Participants With Type 2 Diabetes Mellitus

    Not yet reported Shanghai Minwei Biotechnology Co., Ltd 240 participants Est. completion 2027-03 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT00696657

    A Randomised Controlled Clinical Trial in Type 2 Diabetes Comparing Semaglutide to Placebo and Liraglutide

    Not yet reported Novo Nordisk A/S 415 participants Est. completion 2009-02-05 77 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT00813020

    A Clinical Trial Investigating the Comparison of Three Different Concentrations of NN9535 in Healthy Male Subjects

    Not yet reported Novo Nordisk A/S 44 participants Est. completion 2009-04 1 site
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT00833716

    Effect of Renal Impairment on the Pharmacokinetics of NN9535

    Not yet reported Novo Nordisk A/S 62 participants Est. completion 2010-07-26 3 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes, Renal Impairment
    View official trial listing →
  • Completed NCT NCT00851773

    Safety, Tolerability, and Profile of Action of Drug in the Body of NN9535 in Healthy Male Japanese and Caucasian Subjects

    Not yet reported Novo Nordisk A/S 84 participants Est. completion 2009-10 1 site
    Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT01272973

    Investigation on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NN9924 in Healthy Male Subjects

    Not yet reported Novo Nordisk A/S 96 participants Est. completion 2011-07 1 site Stand-alone
    Type 2 diabetes Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT01324505

    Effect of Oral Contraceptives After Administration of Semaglutide in Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 43 participants Est. completion 2012-01 1 site
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Enrolling by invitation NCT NCT01511393

    An Active Surveillance Program for Cases of Medullary Thyroid Carcinoma (MTC)

    Novo Nordisk A/S 6750 participants Est. completion 2039-12 1 site
    Type 2 diabetes Other conditions: Diabetes, Medullary Thyroid Carcinoma, Weight Management
    View official trial listing →
  • Completed NCT NCT01572753

    Investigation of Optimal Dosing Conditions for a Long Acting GLP-1 Analogue in Healthy Male Subjects

    Not yet reported Novo Nordisk A/S 161 participants Est. completion 2012-09-08 1 site
    Type 2 diabetes Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT01619345

    Pharmacoscintigraphic Investigation of NN9924 in Healthy Male Subjects

    Not yet reported Novo Nordisk A/S 27 participants Est. completion 2012-08 1 site Stand-alone
    Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT01686945

    Investigation on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of a Long-acting GLP-1 Analogue in Healthy Male Subjects and Male Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 107 participants Est. completion 2013-04-08 1 site
    Type 2 diabetes Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT01720446

    Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 3297 participants Est. completion 2016-03-15 253 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT01766245

    A Randomised, Single Centre, Double-blind, Two-period, Cross-over Trial in Healthy Subjects Investigating the Bioequivalence Between Subcutaneous Injections of Semaglutide Produced by Two Manufacturing Processes

    Not yet reported Novo Nordisk A/S 28 participants Est. completion 2013-05 1 site Stand-alone
    Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT01866748

    Investigation on Safety, Tolerability and Pharmacokinetics of Single and Multiple Doses of a Long-acting GLP-1 Analogue (Semaglutide) in an Oral Formulation in Healthy Male Subjects

    Not yet reported Novo Nordisk A/S 170 participants Est. completion 2014-04 1 site Added to GLP-1
    Type 2 diabetes Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT01885208

    Efficacy and Safety of Semaglutide Once-weekly Versus Exenatide ER 2.0 mg Once-weekly as add-on to 1-2 Oral Antidiabetic Drugs (OADs) in Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 813 participants Est. completion 2015-07-13 146 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT01923181

    Multiple Dose Trial Examining Dose Range, Escalation and Efficacy of Oral Semaglutide in Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 632 participants Est. completion 2014-12-11 103 sites
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT01930188

    Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin and/or TZD in Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 1231 participants Est. completion 2015-10-12 141 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02014259

    Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects With Various Degrees of Impaired Renal Function

    Not yet reported Novo Nordisk A/S 71 participants Est. completion 2014-10-24 4 sites
    Type 2 diabetes Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT02016911

    Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects With Hepatic Impairment

    Not yet reported Novo Nordisk A/S 56 participants Est. completion 2015-01-12 6 sites
    Type 2 diabetes Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT02022254

    Influence of Semaglutide on Pharmacokinetics and Pharmacodynamics of Warfarin and Pharmacokinetics of Metformin in Healthy Subjects

    Not yet reported Novo Nordisk A/S 24 participants Est. completion 2014-08-28 1 site Stand-alone
    Type 2 diabetes Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT02054897

    Efficacy and Safety of Semaglutide Once-weekly Versus Placebo in Drug-naïve Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 388 participants Est. completion 2015-05-08 86 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02060266

    Trial Investigating the Absorption, Metabolism and Excretion After a Single Subcutaneous Dose of [3H]-Semaglutide in Healthy Male Subjects

    Not yet reported Novo Nordisk A/S 7 participants Est. completion 2014-04-28 1 site
    Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT02064348

    A Thorough QTc Evaluation of the Effect of Semaglutide on Cardiac Repolarisation in Healthy Subjects

    Not yet reported Novo Nordisk A/S 168 participants Est. completion 2015-04-23 1 site Stand-alone
    Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT02070510

    A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Lisinopril and Warfarin in Healthy Subjects

    Not yet reported Novo Nordisk A/S 52 participants Est. completion 2014-08-20 1 site
    Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT02128932

    Efficacy and Safety of Semaglutide Once Weekly Versus Insulin Glargine Once Daily as add-on to Metformin With or Without Sulphonylurea in Insulin-naïve Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 1089 participants Est. completion 2015-09-03 231 sites
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02146079

    A Trial to Assess the Pharmacokinetics, Pharmacodynamics, and the Safety and Tolerability of Semaglutide in Healthy Male Japanese and Caucasian Subjects

    Not yet reported Novo Nordisk A/S 44 participants Est. completion 2014-10-20 1 site Stand-alone
    Type 2 diabetes Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT02147431

    A Trial Investigating the Effect of Semaglutide on Hypoglycaemic Counterregulation Compared to Placebo in Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 38 participants Est. completion 2015-05-20 1 site
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02161588

    A Trial to Assess the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Oral Semaglutide in Healthy Male Japanese and Caucasian Subjects

    Not yet reported Novo Nordisk A/S 48 participants Est. completion 2014-11 1 site
    Type 2 diabetes Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT02172313

    Effect of Food on the Pharmacokinetics of Oral Semaglutide in Healthy Subjects

    Not yet reported Novo Nordisk A/S 78 participants Est. completion 2014-10 1 site
    Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT02207374

    A Trial Comparing the Safety and Efficacy of Semaglutide Once Weekly in Monotherapy or in Combination With One OAD in Japanese Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 601 participants Est. completion 2016-02-27 43 sites
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02210871

    Investigating the Pharmacokinetics, Safety and Tolerability After a Single Subcutaneous Injection of Semaglutide in Subjects With Mild, Moderate or Severe Hepatic Impairment Compared to Subjects With Normal Hepatic Function

    Not yet reported Novo Nordisk A/S 44 participants Est. completion 2015-06-03 4 sites
    Type 2 diabetes Other conditions: Diabetes, Hepatic Impaired
    View official trial listing →
  • Completed NCT NCT02212067

    A Trial Investigating the Effects of Semaglutide on ß-cell Function in Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 87 participants Est. completion 2015-05-11 1 site Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02231684

    Investigating the Pharmacokinetics of Subcutaneous Injections With 1 mg/mL, 3 mg/mL, and 10 mg/mL Semaglutide Strengths and the Absolute Bioavailability of Semaglutide

    Not yet reported Novo Nordisk A/S 42 participants Est. completion 2015-01 1 site
    Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT02243098

    Investigating the Influence of Semaglutide on the Pharmacokinetics of Single Doses of Atorvastatin and Digoxin in Healthy Subjects

    Not yet reported Novo Nordisk A/S 31 participants Est. completion 2015-04-07 1 site Stand-alone
    Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT02249871

    Investigating the Influence of Omeprazole on the Pharmacokinetics of Oral Semaglutide in Healthy Subjects

    Not yet reported Novo Nordisk A/S 54 participants Est. completion 2015-04-01 1 site Stand-alone
    Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT02249910

    Investigating the Influence of Oral Semaglutide on Pharmacokinetics of Metformin and Digoxin in Healthy Subjects

    Not yet reported Novo Nordisk A/S 32 participants Est. completion 2015-03-06 1 site Stand-alone
    Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT02254291

    A Trial Comparing the Safety and Efficacy of Semaglutide Once Weekly Versus Sitagliptin Once Daily in Japanese Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 308 participants Est. completion 2015-11-11 25 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02305381

    Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to Basal Insulin Alone or Basal Insulin in Combination With Metformin in Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 397 participants Est. completion 2015-11-21 99 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02453711

    Investigation of Safety and Efficacy of Once-daily Semaglutide in Obese Subjects Without Diabetes Mellitus

    Not yet reported Novo Nordisk A/S 957 participants Est. completion 2017-04-12 74 sites Stand-alone
    Other conditions: Metabolism and Nutrition Disorder, Obesity
    View official trial listing →
  • Completed NCT NCT02461589

    Dose-finding of Semaglutide Administered Subcutaneously Once Daily Versus Placebo and Liraglutide in Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 706 participants Est. completion 2016-10-13 150 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02557620

    Comparing Semaglutide Administered Subcutaneously Once Daily to Semaglutide Administered Subcutaneously Once Weekly

    Not yet reported Novo Nordisk A/S 113 participants Est. completion 2016-04 1 site Stand-alone
    Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT02607865

    Efficacy and Long-term Safety of Oral Semaglutide Versus Sitagliptin in Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 1864 participants Est. completion 2018-03-28 242 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02648204

    Efficacy and Safety of Semaglutide Versus Dulaglutide as add-on to Metformin in Subjects With Type 2 Diabetes.

    Not yet reported Novo Nordisk A/S 1201 participants Est. completion 2017-05-19 209 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02692716

    A Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 3183 participants Est. completion 2018-09-25 228 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02773381

    A Trial Investigating the Effect of Oral Semaglutide Compared With Placebo on Postprandial Glucose and Triglyceride Metabolism, Energy Intake, Appetite Sensations and Gastric Emptying in Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 15 participants Est. completion 2018-10-19 1 site
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02827708

    Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes and Moderate Renal Impairment

    Not yet reported Novo Nordisk A/S 324 participants Est. completion 2018-05-15 117 sites
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02845219

    A Trial Investigating the Influence of Oral Semaglutide on Pharmacokinetics of Ethinylestradiol and Levonorgestrel in an Oral Contraceptive Combination Drug in Healthy Postmenopausal Females

    Not yet reported Novo Nordisk A/S 25 participants Est. completion 2016-12 1 site Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02849080

    Efficacy and Safety of Oral Semaglutide Using a Flexible Dose Adjustment Based on Clinical Evaluation Versus Sitagliptin in Subjects With Type 2 Diabetes Mellitus.

    Not yet reported Novo Nordisk A/S 504 participants Est. completion 2019-03-27 83 sites
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02863328

    Efficacy and Safety of Oral Semaglutide Versus Empagliflozin in Subjects With Type 2 Diabetes Mellitus

    Not yet reported Novo Nordisk A/S 822 participants Est. completion 2018-03-08 106 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02863419

    Efficacy and Safety of Oral Semaglutide Versus Liraglutide and Versus Placebo in Subjects With Type 2 Diabetes Mellitus

    Not yet reported Novo Nordisk A/S 711 participants Est. completion 2018-03-30 108 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02877355

    Investigation of the Effect of Upper Gastrointestinal Disease on the Pharmacokinetics of Oral Semaglutide in Subjects With Type 2 Diabetes.

    Not yet reported Novo Nordisk A/S 55 participants Est. completion 2017-11-24 2 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02906930

    Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Diet and Exercise Only

    Not yet reported Novo Nordisk A/S 703 participants Est. completion 2017-12-08 105 sites Added to GLP-1
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT02920385

    A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Levothyroxine and the Influence of Co-administered Tablets on the Pharmacokinetics of Semaglutide Administered Orally in Healthy Subjects.

    Not yet reported Novo Nordisk A/S 45 participants Est. completion 2017-06-16 1 site Stand-alone
    Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT02970942

    Investigation of Efficacy and Safety of Three Dose Levels of Subcutaneous Semaglutide Once Daily Versus Placebo in Subjects With Non-alcoholic Steatohepatitis.

    Not yet reported Novo Nordisk A/S 320 participants Est. completion 2020-03-19 158 sites Stand-alone
    Other conditions: Hepatobiliary Disorders, Non-alcoholic Steatohepatitis
    View official trial listing →
  • Completed NCT NCT03010475

    A Trial Investigating the Effect of Oral Semaglutide on the Pharmacokinetics of Furosemide and Rosuvastatin in Healthy Subjects

    Not yet reported Novo Nordisk A/S 41 participants Est. completion 2017-08-09 1 site Stand-alone
    Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT03015220

    Safety and Efficacy of Oral Semaglutide Versus Dulaglutide Both in Combination With One OAD (Oral Antidiabetic Drug) in Japanese Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 458 participants Est. completion 2018-07-12 34 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT03018028

    Dose-response, Safety and Efficacy of Oral Semaglutide Versus Placebo and Versus Liraglutide, All as Monotherapy in Japanese Subjects With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 243 participants Est. completion 2018-08-15 16 sites Added to GLP-1
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT03021187

    Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Insulin

    Not yet reported Novo Nordisk A/S 731 participants Est. completion 2018-08-22 118 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT03061214

    Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin in Subjects With Type 2 Diabetes (SUSTAIN - CHINA MRCT)

    Not yet reported Novo Nordisk A/S 868 participants Est. completion 2019-04-15 67 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT03086330

    Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to SGLT-2i in Subjects With Type 2 Diabetes Mellitus

    Not yet reported Novo Nordisk A/S 302 participants Est. completion 2018-08-06 72 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT03144271

    Dose Escalation Trial of Single Subcutaneous Doses of NNC 0113-0217 to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Male Subjects

    Not yet reported Novo Nordisk A/S 58 participants Est. completion 2007-10-08 1 site
    Type 2 diabetes Other conditions: Diabetes, Healthy
    View official trial listing →
  • Completed NCT NCT03191396

    Research Study Comparing a New Medicine Semaglutide to Liraglutide in People With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 577 participants Est. completion 2018-08-13 92 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT03288740

    A Trial to Assess the Pharmacokinetics, Safety and Tolerability of Semaglutide in Healthy Chinese Subjects

    Not yet reported Novo Nordisk A/S 36 participants Est. completion 2018-08-07 1 site Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT03292315

    Once Weekly GLP-1 in Persons With Spinal Cord Injury

    Not yet reported James J. Peters Veterans Affairs Medical Center 5 participants Est. completion 2023-03-01 1 site
    Other conditions: Spinal Cord Injuries, Insulin Resistance, Pre Diabetes, Obesity
    View official trial listing →
  • Completed NCT NCT03357380

    A Study on How Semaglutide Works on Early Stages of Scar Tissue in the Liver Assessed by Pictures of the Liver

    Not yet reported Novo Nordisk A/S 67 participants Est. completion 2020-03-20 2 sites Stand-alone
    Other conditions: Hepatobiliary Disorders, Non-alcoholic Fatty Liver Disease
    View official trial listing →
  • Completed NCT NCT03457012

    A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Canada, as Part of Local Clinical Practice

    Novo Nordisk A/S 462 participants Est. completion 2019-12-19 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT03466567

    A Trial Investigating the Effect of Probenecid and Ciclosporin on the Concentrations of SNAC in Healthy Subjects

    Not yet reported Novo Nordisk A/S 21 participants Est. completion 2018-07-10 1 site Stand-alone
    Type 2 diabetes Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT03498001

    Effects of GLP-1 Agonists on CArdiac Steatosis Evaluated by Magnetic Resonance Imaging

    Not yet reported Centre Hospitalier Universitaire Dijon 42 participants Est. completion 2023-12-20 1 site Stand-alone
    Other conditions: Type II Diabetes
    View official trial listing →
  • Completed NCT NCT03548935

    STEP 1: Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity

    Not yet reported Novo Nordisk A/S 1961 participants Est. completion 2021-03-05 128 sites
    Other conditions: Metabolism and Nutrition Disorder, Overweight or Obesity
    View official trial listing →
  • Completed NCT NCT03548987

    Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity

    Not yet reported Novo Nordisk A/S 902 participants Est. completion 2020-03-20 72 sites Stand-alone
    Other conditions: Metabolism and Nutrition Disorder, Obesity
    View official trial listing →
  • Completed NCT NCT03552757

    Research Study Investigating How Well Semaglutide Works in People With Type 2 Diabetes Suffering From Overweight or Obesity

    Not yet reported Novo Nordisk A/S 1210 participants Est. completion 2020-05-01 147 sites Stand-alone
    Other conditions: Obesity, Overweight
    View official trial listing →
  • Completed NCT NCT03574584

    A Research Study of NNC0165-1562 and Semaglutide in People Who Are Overweight or Obese

    Not yet reported Novo Nordisk A/S 37 participants Est. completion 2019-07-27 2 sites Stand-alone
    Other conditions: Metabolism and Nutrition Disorders, Overweight or Obesity
    View official trial listing →
  • Completed NCT NCT03574597

    Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity

    Not yet reported Novo Nordisk A/S 17604 participants Est. completion 2023-06-29 833 sites Stand-alone
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT03596450

    Long Term Comparative Effectiveness of Once Weekly Semaglutide Versus Standard of Care in a Real World Adult US Population With Type 2 Diabetes - a Randomized Pragmatic Trial

    Not yet reported Novo Nordisk A/S 1278 participants Est. completion 2023-06-09 122 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT03598621

    A Research Study to Look at Similarity Between Semaglutide Versions in Different Injection Tools

    Not yet reported Novo Nordisk A/S 68 participants Est. completion 2019-01-17 2 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT03600480

    A Research Study of How NNC0174-0833 Taken With Semaglutide Works in People Who Are Overweight or Obese

    Not yet reported Novo Nordisk A/S 96 participants Est. completion 2020-06-12 1 site Stand-alone
    Other conditions: Obesity, Overweight
    View official trial listing →
  • Completed NCT NCT03611322

    A Trial to Compare Blood Concentration Levels of Semaglutide Following Subcutaneous Injections of Semaglutide 1 mg by 2 Different Devices (the DV3372 Device and by the PDS290 Semaglutide Pen-injector)

    Not yet reported Novo Nordisk A/S 54 participants Est. completion 2019-01-07 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT03611582

    Research Study to Look at How Well Semaglutide is at Lowering Weight When Taken Together With an Intensive Lifestyle Program

    Not yet reported Novo Nordisk A/S 611 participants Est. completion 2020-04-28 41 sites
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT03631186

    A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Switzerland, as Part of Local Clinical Practice (SURE SWITZERLAND)

    Novo Nordisk A/S 215 participants Est. completion 2019-12-18 28 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT03638778

    Research Study Comparing Different Tablets With the Study Medicine Semaglutide in Healthy Men

    Not yet reported Novo Nordisk A/S 105 participants Est. completion 2018-12-05 1 site Added to GLP-1
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT03648281

    A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Denmark and Sweden, as Part of Local Clinical Practice (SURE DENMARK/SWEDEN)

    Novo Nordisk A/S 333 participants Est. completion 2020-01-10 30 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT03689374

    A Research Study to Compare Semaglutide to Insulin Aspart, When Taken Together With Metformin and Insulin Glargine, in People With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 2274 participants Est. completion 2021-02-22 210 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT03693430

    Two-year Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity

    Not yet reported Novo Nordisk A/S 304 participants Est. completion 2021-03-23 41 sites
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT03707990

    A Research Study of NNC0165-1875 Alone or Together With Semaglutide in People Who Are Overweight or Obese

    Not yet reported Novo Nordisk A/S 88 participants Est. completion 2019-08-13 1 site Stand-alone
    Other conditions: Obesity and Overweight
    View official trial listing →
  • Completed NCT NCT03789578

    A Research Study to Look at How Insulin 287 and Semaglutide Work in the Body of People With Type 2 Diabetes When Taken Alone or Together

    Not yet reported Novo Nordisk A/S 30 participants Est. completion 2019-10-10 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Active, not recruiting NCT NCT03811561

    A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 1500 participants Est. completion 2027-11-07 230 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT03811574

    STEP 6: Research Study Investigating How Well Semaglutide Works in People Living With Overweight or Obesity

    Not yet reported Novo Nordisk A/S 401 participants Est. completion 2020-11-20 28 sites Added to GLP-1
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT03842202

    A Research Study to Look at How Semaglutide Affects Gastric Emptying in People With Obesity

    Not yet reported Novo Nordisk A/S 72 participants Est. completion 2019-11-04 1 site Stand-alone
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT03876015

    A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in United Kingdom, as Part of Local Clinical Practice (SURE UK)

    Novo Nordisk A/S 215 participants Est. completion 2020-08-12 31 sites
    Type 2 diabetes
    View official trial listing →
  • Active, not recruiting NCT NCT03899402

    Triple Therapy in T1DM

    Not yet reported, Not yet reported State University of New York at Buffalo 78 participants Est. completion 2026-06-30 1 site
    Other conditions: Type 1 Diabetes Mellitus
    View official trial listing →
  • Completed NCT NCT03914326

    A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 9651 participants Est. completion 2024-08-23 492 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT03919929

    Treating PCOS With Semaglutide vs Active Lifestyle Intervention

    Not yet reported, Not yet reported University of Colorado, Denver 60 participants Est. completion 2023-10-03 1 site
    MASLD Other conditions: PCOS, Adolescent Obesity
    View official trial listing →
  • Completed NCT NCT03929679

    A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in The Netherlands, as Part of Local Clinical Practice (SURE NETHERLANDS)

    Novo Nordisk A/S 218 participants Est. completion 2020-11-24 27 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT03951753

    A Study of Tirzepatide in Participants With Type 2 Diabetes Mellitus (T2DM)

    Not yet reported Eli Lilly and Company 117 participants Est. completion 2021-04-08 2 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT03985384

    Semaglutide Treatment On Coronary Progression

    Not yet reported Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center 140 participants Est. completion 2022-12-27 1 site
    Type 2 diabetesCardiovascular disease
    View official trial listing →
  • Completed NCT NCT03987451

    A Research Study on How Semaglutide Works in People With Fatty Liver Disease and Liver Damage

    Not yet reported Novo Nordisk A/S 71 participants Est. completion 2021-06-10 38 sites Stand-alone
    Other conditions: Non-alcoholic Steatohepatitis
    View official trial listing →
  • Completed NCT NCT03987919

    A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes

    Not yet reported Eli Lilly and Company 1879 participants Est. completion 2021-02-15 127 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT03989232

    A Research Study to Compare Two Doses of Semaglutide Taken Once Weekly in People With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 961 participants Est. completion 2020-11-09 129 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04007107

    A Study Comparing the Injection Site Pain Experience After the Injection of 2 Different Solutions of Semaglutide With 2 Different Injection Pens, a Compound for the Treatment of Type 2 Diabetes and Obesity

    Not yet reported Novo Nordisk A/S 103 participants Est. completion 2019-09-04 1 site
    Type 2 diabetes Other conditions: Healthy Volunteers Overweight, Healthy Volunteers Obesity
    View official trial listing →
  • Terminated NCT NCT04012255

    A Research Study to Compare Two Forms of Semaglutide in Two Different Pen-injectors in People With Overweight or Obesity

    Not yet reported Novo Nordisk A/S 29 participants Est. completion 2019-10-22 2 sites
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT04016974

    A Research Study of How Oral Semaglutide Tablets Work in Healthy People Who Are Chinese

    Not yet reported Novo Nordisk A/S 32 participants Est. completion 2021-02-26 1 site Added to GLP-1
    Type 2 diabetes Other conditions: Healthy Volunteers
    View official trial listing →
  • Completed NCT NCT04017832

    A Research Study Comparing a New Medicine Oral Semaglutide to Sitagliptin in People With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 1441 participants Est. completion 2021-10-27 93 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Active, not recruiting NCT NCT04019197

    Effects of Semaglutide in HIV-Associated Lipohypertrophy

    Not yet reported Case Western Reserve University 108 participants Est. completion 2026-09-01 2 sites Stand-alone
    Other conditions: HIV/AIDS, Lipohypertrophy, Obesity
    View official trial listing →
  • Completed NCT NCT04032197

    A Research Study of How Semaglutide Works in People With Disease Affecting the Heart and/or Blood Vessels and Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 101 participants Est. completion 2023-06-06 4 sites
    Type 2 diabetes
    View official trial listing →
  • Status unknown NCT NCT04061200

    Renal Effects of Treatment With Empagliflozin Alone or in Combination With Semaglutide in Patients With Type 2 Diabetes and Albuminuria

    Not yet reported Steno Diabetes Center Copenhagen 80 participants Est. completion 2021-08-01 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04067999

    A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Spain, as Part of Local Clinical Practice

    Novo Nordisk A/S 230 participants Est. completion 2021-07-19 16 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04074161

    Research Study to Investigate How Well Semaglutide Works Compared to Liraglutide in People Living With Overweight or Obesity

    Not yet reported Novo Nordisk A/S 338 participants Est. completion 2021-05-11 19 sites Stand-alone
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT04083820

    A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in France, as Part of Local Clinical Practice (SURE FRANCE)

    Novo Nordisk A/S 521 participants Est. completion 2021-09-27 53 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04094415

    A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Italy, as Part of Local Clinical Practice

    Novo Nordisk A/S 581 participants Est. completion 2021-07-28 39 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04097600

    A Research Study Comparing Active Drug in the Blood in Healthy Participants Following Dosing of the Current and a New Formulation (D) Semaglutide Tablets

    Not yet reported Novo Nordisk A/S 274 participants Est. completion 2021-01-20 1 site Stand-alone
    Type 2 diabetes Other conditions: Healthy Volunteers
    View official trial listing →
  • Completed NCT NCT04102189

    A Research Study on How Well Semaglutide Works in Adolescents With Overweight or Obesity

    Not yet reported Novo Nordisk A/S 201 participants Est. completion 2022-03-28 51 sites Stand-alone
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT04109508

    A Research Study Comparing Active Drug in the Blood in Healthy Participants Following Dosing of the Current and a New Formulation (C) Semaglutide Tablets

    Not yet reported Novo Nordisk A/S 278 participants Est. completion 2021-01-27 1 site
    Type 2 diabetes Other conditions: Healthy Volunteers
    View official trial listing →
  • Completed NCT NCT04109547

    A Research Study Comparing a New Medicine Oral Semaglutide to Placebo in People With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 521 participants Est. completion 2021-10-27 66 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04126603

    Impact of Semaglutide on CD34+ EPC and Fat Derived MSC

    Not yet reported Sabyasachi Sen 10 participants Est. completion 2025-05-14 2 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04143945

    A Study Comparing the Injection Site Pain Experience After the Injection of Semaglutide B and Semaglutide D With 2 Different Injection Pens, a Compound for the Treatment of Type 2 Diabetes and Obesity

    Not yet reported Novo Nordisk A/S 104 participants Est. completion 2020-01-04 1 site
    Type 2 diabetes Other conditions: Healthy Volunteers Overweight, Healthy Volunteers Obesity
    View official trial listing →
  • Completed NCT NCT04152915

    A Research Study Looking at Similarity Between Once-weekly Semaglutide Versions for Different Injection Pens

    Not yet reported Novo Nordisk A/S 68 participants Est. completion 2020-05-25 1 site
    Type 2 diabetes Other conditions: Healthy Volunteers
    View official trial listing →
  • Completed NCT NCT04153929

    A Study to Test Whether Different Doses of BI 456906 Are Effective in Treating Adults With Type 2 Diabetes.

    Not yet reported Boehringer Ingelheim 413 participants Est. completion 2021-11-04 80 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04175665

    Real-world Health Outcomes in Canadian Patients Using Semaglutide

    LMC Diabetes & Endocrinology Ltd. 1133 participants Est. completion 2020-02-09 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04189848

    Comparison of Injection Site Pain Experience for Semaglutide and Dulaglutide sc

    Not yet reported Novo Nordisk A/S 104 participants Est. completion 2020-02-27 1 site Added to GLP-1
    Type 2 diabetes Other conditions: Healthy Volunteers, Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT04200625

    Semaglutide vs Dulaglutide on Epicardial Adipose Tissue

    University of Miami 80 participants Est. completion 2019-12-09 1 site
    Other conditions: Epicardial Fat
    View official trial listing →
  • Completed NCT NCT04216589

    Study of Semaglutide for Non-Alcoholic Fatty Liver Disease (NAFLD), a Metabolic Syndrome With Insulin Resistance, Increased Hepatic Lipids, and Increased Cardiovascular Disease Risk (The SLIM LIVER Study)

    Not yet reported National Institute of Allergy and Infectious Diseases (NIAID) 51 participants Est. completion 2023-09-15 9 sites Stand-alone
    Other conditions: HIV Infections, Non-Alcoholic Fatty Liver Disease
    View official trial listing →
  • Completed NCT NCT04228354

    A Research Study Looking at the Comparability (Bioequivalence) of Two Versions of Semaglutide

    Not yet reported Novo Nordisk A/S 28 participants Est. completion 2020-06-01 1 site
    Other conditions: Healthy Volunteers, Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT04251156

    Research Study of How Well Semaglutide Works in People Living With Overweight or Obesity.

    Not yet reported Novo Nordisk A/S 375 participants Est. completion 2022-08-23 33 sites
    Type 2 diabetes Other conditions: Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT04259801

    First Research Study to Look at How Two Medicines, NNC0480-0389 and Semaglutide, Work Together in Healthy People, in People With High Body Weight and in People With Diabetes

    Not yet reported Novo Nordisk A/S 152 participants Est. completion 2022-03-16 1 site Stand-alone
    Type 2 diabetes Other conditions: Healthy Volunteers, Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT04261933

    A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Germany, as Part of Local Clinical Practice (SURE GERMANY)

    Novo Nordisk A/S 789 participants Est. completion 2021-05-25 95 sites
    Type 2 diabetes
    View official trial listing →
  • Withdrawn NCT NCT04287179

    SUSTAIN SWITCH: A Research Study to Compare Two Dose Schedules of Semaglutide Taken Once Weekly in People With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S Est. completion 2021-01-25 25 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Status unknown NCT NCT04383197

    Exercise and GLP-1 RA on Insulin Secretion

    Not yet reported University of Copenhagen 30 participants Est. completion 2022-08 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Status unknown NCT NCT04447859

    16-week Flexible vs. 8-week Semaglutide Titration

    Not yet reported Tel-Aviv Sourasky Medical Center 100 participants Est. completion 2022-09-10 1 site
    Other conditions: Diabetes type2
    View official trial listing →
  • Active, not recruiting NCT NCT04451837

    Semaglutide and Dapagliflozin in Diabetic Patients With Different Pathophysiology

    Not yet reported Region Skane 200 participants Est. completion 2026-12-31 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04466345

    Semaglutide for the Treatment of Cognitive Dysfunction in Major Depressive Disorder

    Not yet reported University Health Network, Toronto 72 participants Est. completion 2024-12-27 1 site
    Other conditions: Major Depressive Disorder
    View official trial listing →
  • Completed NCT NCT04469855

    Post-Marketing Surveillance (Special Use-results Surveillance) on Long-term Use With Ozempic®

    Novo Nordisk A/S 3217 participants Est. completion 2025-05-12 414 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04513704

    A Clinical Trial Comparing Semaglutide in Healthy People Who Eat and Take the Medicine at Different Times

    Not yet reported Novo Nordisk A/S 156 participants Est. completion 2021-05-26 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04515849

    A Study of Cotadutide in Participants Who Have Chronic Kidney Disease With Type 2 Diabetes Mellitus

    Not yet reported AstraZeneca 248 participants Est. completion 2022-03-08 83 sites
    Type 2 diabetesChronic kidney disease
    View official trial listing →
  • Completed NCT NCT04524832

    Research Study Comparing New Tablets of Semaglutide in New Doses, in Healthy People

    Not yet reported Novo Nordisk A/S 290 participants Est. completion 2022-02-25 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04537624

    A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Switzerland, as Part of Local Clinical Practice

    Novo Nordisk A/S 194 participants Est. completion 2023-05-31 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04537637

    A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Denmark, as Part of Local Clinical Practice

    Novo Nordisk A/S 99 participants Est. completion 2023-05-08 2 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04538352

    Transition From Basal/Bolus to Once-weekly Subcutaneous Semaglutide and Basal Insulin in Patients With T2D

    Not yet reported The Cleveland Clinic 60 participants Est. completion 2023-11-01 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04559815

    A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Canada, as Part of Local Clinical Practice

    Novo Nordisk A/S 194 participants Est. completion 2022-09-14 2 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04560998

    A Research Study to Compare a Medicine Called Semaglutide Against Placebo in People With Peripheral Arterial Disease and Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 792 participants Est. completion 2024-07-12 283 sites
    Type 2 diabetes Other conditions: Peripheral Arterial Disease
    View official trial listing →
  • Completed NCT NCT04572165

    Epidemiological Assessment of the Risk for Pancreatic Cancer Associated With the Use of Semaglutide in Patients With Type 2 Diabetes - A Cohort Study Based on Nordic Registry Data

    Novo Nordisk A/S 194928 participants Est. completion 2025-11-25 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04596631

    A Research Study to Compare a New Medicine Oral Semaglutide to a Dummy Medicine in Children and Teenagers With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 132 participants Est. completion 2026-02-03 97 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04601740

    A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in The Netherlands, as Part of Local Clinical Practice

    Novo Nordisk A/S 145 participants Est. completion 2022-12-19 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04601753

    A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Sweden, as Part of Local Clinical Practice

    Novo Nordisk A/S 194 participants Est. completion 2023-03-03 1 site
    Type 2 diabetes
    View official trial listing →
  • Status unknown NCT NCT04615871

    Semaglutide to Reduce Myocardial Injury in PATIents With COVID-19

    Not yet reported Vladimír Džavík 400 participants Est. completion 2022-03-31 10 sites Stand-alone
    Other conditions: Covid19, Myocardial Injury
    View official trial listing →
  • Terminated NCT NCT04624672

    Treatment of GLP-1 for Diabetic Bariatric Patients

    Not yet reported Geisinger Clinic 3 participants Est. completion 2022-08-17 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04639414

    Combined Active Treatment in Type 2 Diabetes With NASH

    Not yet reported German Diabetes Center 192 participants Est. completion 2025-11-17 26 sites Stand-alone
    Type 2 diabetesMASHMASLD
    View official trial listing →
  • Completed NCT NCT04707469

    Research Study to Compare Three Doses of Semaglutide Tablets Taken Once Daily in People With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 1606 participants Est. completion 2023-03-08 228 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Terminated NCT NCT04741074

    Effect of Subcutaneous Semaglutide on Kidney Transplant Candidacy

    Not yet reported Geisinger Clinic 15 participants Est. completion 2023-01-31 2 sites
    Chronic kidney diseaseType 2 diabetes Other conditions: Obesity, Severe Obesity
    View official trial listing →
  • Completed NCT NCT04777396

    A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE)

    Not yet reported Novo Nordisk A/S 1840 participants Est. completion 2026-01-30 447 sites Stand-alone
    Other conditions: Early Alzheimer's Disease
    View official trial listing →
  • Completed NCT NCT04777409

    A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus)

    Not yet reported Novo Nordisk A/S 1840 participants Est. completion 2026-01-30 498 sites Stand-alone
    Other conditions: Early Alzheimer´s Disease
    View official trial listing →
  • Completed NCT NCT04779697

    GLP-1 Analogue Effects on Food Cues, Stress, Motivation for Highly Palatable Foods, and Weight

    Not yet reported Yale University 96 participants Est. completion 2024-11-19 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT04788511

    Research Study to Investigate How Well Semaglutide Works in People Living With Heart Failure and Obesity

    Not yet reported Novo Nordisk A/S 529 participants Est. completion 2023-04-18 146 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT04817644

    A Research Study to See How Much Semaglutide and SNAC is in the Milk of Healthy, Breastfeeding Women Taking Semaglutide Tablets

    Not yet reported Novo Nordisk A/S 14 participants Est. completion 2023-07-03 2 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Active, not recruiting NCT NCT04822181

    Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)

    Not yet reported Novo Nordisk A/S 1205 participants Est. completion 2029-04-25 558 sites Stand-alone
    Other conditions: Non-alcoholic Steatohepatitis
    View official trial listing →
  • Status unknown NCT NCT04854083

    Semaglutide as an Adjunct to Dieting in the Treatment of Type 2 Diabetes

    Not yet reported Kirsi Pietiläinen 50 participants Est. completion 2025-08 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04862923

    A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in the United Kingdom, as Part of Local Clinical Practice

    Novo Nordisk A/S 336 participants Est. completion 2023-08-31 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04865744

    The Effect of Semaglutide on Pituitary Function

    Not yet reported University of Tartu 10 participants Est. completion 2021-09-30 1 site
    Other conditions: Healthy
    View official trial listing →
  • Completed NCT NCT04865770

    A Research Study to Find Out How Semaglutide Works in the Kidneys Compared to Placebo, in People With Type 2 Diabetes and Chronic Kidney Disease (the REMODEL Trial)

    Not yet reported Novo Nordisk A/S 106 participants Est. completion 2024-11-21 49 sites Stand-alone
    Type 2 diabetesChronic kidney disease
    View official trial listing →
  • Completed NCT NCT04873245

    Lifestyle Counseling and Medication for Adolescent Weight Management

    Not yet reported University of Minnesota 120 participants Est. completion 2026-06-30 1 site
    Other conditions: Obesity, Childhood
    View official trial listing →
  • Completed NCT NCT04878393

    A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Japan, as Part of Local Clinical Practice

    Novo Nordisk A/S 650 participants Est. completion 2023-02-09 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT04878406

    A Research Study of How the Medicine NNC0480-0389 Taken With Semaglutide Works in the Body of Healthy Japanese Men

    Not yet reported Novo Nordisk A/S 24 participants Est. completion 2021-07-20 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Withdrawn NCT NCT04885634

    Semaglutide for the Reduction of Arrhythmia Burden in Overweight AF Patients

    Not yet reported Axel Brandes Est. completion 2024-11
    Other conditions: Atrial Fibrillation, Overweight and Obesity
    View official trial listing →
  • Completed NCT NCT04889183

    SeMaglutide and Albuminuria Reduction Trial in Obese Individuals Without Diabetes

    Not yet reported University Medical Center Groningen 125 participants Est. completion 2024-05-28 13 sites
    Other conditions: Obesity, Albuminuria
    View official trial listing →
  • Active, not recruiting NCT NCT04892199

    Does GLP-1RA Prevent Deterioration of Metabolic State in Prediabetic and Diabetic Patients Treated With Antipsychotic Medication?

    Not yet reported Anders Fink-Jensen, MD, DMSci 104 participants Est. completion 2026-08-01 3 sites
    Type 2 diabetes Other conditions: Metabolic Disturbance, Schizophrenia, Clozapine, GLP-1, Olanzapine
    View official trial listing →
  • Completed NCT NCT04916470

    Research Study to Look at How Well Semaglutide Works in People Living With Heart Failure, Obesity and Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 617 participants Est. completion 2023-10-11 180 sites Added to GLP-1
    Type 2 diabetesHeart failure
    View official trial listing →
  • Terminated NCT NCT04938388

    Comparison of Oral Semaglutide w/ Placebo- Treatment for Latino Adults w/T2 Diabetes Receiving Enhanced Lifestyle Care

    Not yet reported Sansum Diabetes Research Institute 12 participants Est. completion 2023-02-16 1 site
    Type 2 diabetes Other conditions: Glucose Metabolism Disorders (Including Diabetes Mellitus)
    View official trial listing →
  • Completed NCT NCT04940078

    A Research Study to Compare Blood Levels of Cagrilintide and Semaglutide After Combined Versus Separate Injections in People With Overweight or Obesity

    Not yet reported Novo Nordisk A/S 40 participants Est. completion 2022-02-16 2 sites Stand-alone
    Other conditions: Obesity & Overweight
    View official trial listing →
  • Completed NCT NCT04944992

    A Study of Efinopegdutide (MK-6024) in Participants With Nonalcoholic Fatty Liver Disease (NAFLD) (MK-6024-001)

    Not yet reported Merck Sharp & Dohme LLC 145 participants Est. completion 2022-10-19 69 sites
    MASLDMASH
    View official trial listing →
  • Completed NCT NCT04969939

    A Research Study to Investigate How Well NNC0165-1875 in Combination With Semaglutide Works in People With Obesity

    Not yet reported Novo Nordisk A/S 120 participants Est. completion 2023-01-30 25 sites Added to GLP-1
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT04972721

    SELECT-LIFE: A Research Study Looking at Long-term Effects of Semaglutide in People Who Took Part in the SELECT Cardiovascular Outcomes Trial

    Novo Nordisk A/S 3439 participants Est. completion 2025-08-25 38 sites
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT04979130

    Comparing Semaglutide Versus Placebo on Intestinal Barrier Function in Type 2 Diabetes Mellitus (SIB)

    Not yet reported University of Colorado, Denver 69 participants Est. completion 2024-10-16 1 site Stand-alone
    Type 2 diabetes Other conditions: Chronic Inflammation, Intestinal Permeability
    View official trial listing →
  • Completed NCT NCT04982575

    Research Study to Look at How Well Cagrilintide Together With Semaglutide Works in People With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 92 participants Est. completion 2022-07-07 23 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Status unknown NCT NCT04990024

    The Effect of Different Diets on Arterial Stiffness in Obese Patients on Semaglutide

    Not yet reported American University of Beirut Medical Center 60 participants Est. completion 2025-09-15 1 site
    Other conditions: Obesity, Weight Loss
    View official trial listing →
  • Completed NCT NCT04998136

    Research Study Investigating How Well Semaglutide Works in People From Thailand and South Korea Living With Obesity

    Not yet reported Novo Nordisk A/S 150 participants Est. completion 2023-11-20 16 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT05013229

    A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People With Type 2 Diabetes Compared to Insulin Glargine Taken Daily With Insulin Aspart (COMBINE 3)

    Not yet reported Novo Nordisk A/S 679 participants Est. completion 2023-11-14 182 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05016882

    Research Study on Whether a Combination of 2 Medicines (NNC0194 0499 and Semaglutide) Works in People With Non-alcoholic Steatohepatitis (NASH)

    Not yet reported Novo Nordisk A/S 698 participants Est. completion 2025-03-14 255 sites Stand-alone
    Other conditions: Non-alcoholic Steatohepatitis
    View official trial listing →
  • Completed NCT NCT05035082

    A Research Study Comparing RYBELSUS® to Other Blood Sugar Lowering Tablets in People Living in America With Type 2 Diabetes (REALYSE)

    Not yet reported Novo Nordisk A/S 1018 participants Est. completion 2025-06-18 25 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05035095

    Research Study to Investigate How Well Semaglutide Tablets Taken Once Daily Work in People Who Are Overweight or Living With Obesity (OASIS 1)

    Not yet reported Novo Nordisk A/S 667 participants Est. completion 2023-05-12 56 sites Stand-alone
    Other conditions: Obesity, Overweight
    View official trial listing →
  • Active, not recruiting NCT NCT05040087

    Changing the Natural History of Type 2 Diabetes ("CHANGE" Study)

    Not yet reported Foundation for Atlanta Veterans Education and Research, Inc. 127 participants Est. completion 2028-06-30 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05040971

    Research Study Looking at How Well Semaglutide Works in People Living With Obesity and Prediabetes

    Not yet reported Novo Nordisk A/S 207 participants Est. completion 2023-07-14 43 sites
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT05046873

    A Research Study Looking Into Blood Levels of Semaglutide and NNC0480-0389 When Given in the Same Injection or in Two Separate Injections in Healthy People

    Not yet reported Novo Nordisk A/S 16 participants Est. completion 2022-01-05 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05064735

    Research Study Looking at How Well Semaglutide Works in People Suffering From Obesity and Knee Osteoarthritis

    Not yet reported Novo Nordisk A/S 407 participants Est. completion 2023-09-08 122 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Active, not recruiting NCT NCT05067621

    Semaglutide Effects in Obese Youth With Prediabetes/New Onset Type 2 Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease

    Not yet reported Yale University 60 participants Est. completion 2027-01 1 site
    Type 2 diabetesPrediabetes Other conditions: Non-Alcoholic Fatty Liver Disease, Obesity, Childhood
    View official trial listing →
  • Status unknown NCT NCT05071417

    Effect Of Semaglutide In Coronary Atheroma Plaque

    Not yet reported Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León 120 participants Est. completion 2025-12 Stand-alone
    Other conditions: Atheroscleroses, Coronary
    View official trial listing →
  • Active, not recruiting NCT NCT05073835

    Semaglutide 2.4 mg in Patients With Poor Weight-loss

    Not yet reported University College, London 70 participants Est. completion 2025-09 1 site Stand-alone
    Metabolic syndrome Other conditions: Obesity, Diabetes
    View official trial listing →
  • Completed NCT NCT05078255

    The Separate and Combined Effects of Long-term GIP and GLP-1 Receptor Activation in Patients with Type 2 Diabetes

    Not yet reported Asger Lund, MD 61 participants Est. completion 2025-01-24 1 site
    Type 2 diabetes Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT05087342

    Latino Semaglutide Study

    Not yet reported Loma Linda University 119 participants Est. completion 2024-05-29 1 site
    Other conditions: Obesity, Obesity; Drug, Overweight or Obesity, Weight Loss, Weight Loss Trajectory, Weight, Body
    View official trial listing →
  • Completed NCT NCT05129891

    A Research Study Looking at New Protein-based Tablets in Healthy Male Participants

    Not yet reported Novo Nordisk A/S 384 participants Est. completion 2023-05-04 2 sites Added to GLP-1
    Type 2 diabetes Other conditions: Healthy Volunteers, High Blood Cholesterol Levels
    View official trial listing →
  • Completed NCT NCT05132088

    Research Study to Investigate How Well Semaglutide Tablets Taken Once Daily Work in East Asian People Who Are Overweight or Living With Obesity

    Not yet reported Novo Nordisk A/S 201 participants Est. completion 2023-09-01 15 sites Stand-alone
    Other conditions: Overweight and Obesity
    View official trial listing →
  • Completed NCT NCT05136287

    SEMAGLUTIDE VERSUS GLP-1 RECEPTOR AGONISTS. EFFECTIVENESS , SAFETY AND QUALITY OF LIFE IN PATIENTS WITH DIABETES MELLITUS 2. OBSERVATIONAL, PROSPECTIVE AND MULTICENTER STUDY. SEVERAL STUDY.

    Jose Seijas Amigo 140 participants Est. completion 2024-01-01 11 sites
    Type 2 diabetes Other conditions: Weight Loss, Quality of Life, Safety Issues
    View official trial listing →
  • Completed NCT NCT05144984

    A Research Study Looking at How Well a Combination of the Medicines Semaglutide and NNC0480-0389 Works in People With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 500 participants Est. completion 2023-03-23 129 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Status unknown NCT NCT05147896

    Semaglutide Anti-Atherosclerotic Mechanisms of Action Study in Type 2 Diabetes Patients

    Not yet reported University Medical Centre Ljubljana 100 participants Est. completion 2023-12-01 1 site
    Type 2 diabetes Other conditions: Atherosclerosis
    View official trial listing →
  • Completed NCT NCT05153564

    A Research Study Looking Into the Effect of Semaglutide and NNC0480 0389 on Blood Levels of a Birth Control Pill in Woman After Menopause

    Not yet reported Novo Nordisk A/S 27 participants Est. completion 2022-09-01 1 site
    Type 2 diabetes
    View official trial listing →
  • Status unknown NCT NCT05161429

    BESTMED: Observational Evaluation of Second Line Therapy Medications in Diabetes

    Brigham and Women's Hospital 550000 participants Est. completion 2024-06-30 5 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05193578

    Home-based Intervention With Semaglutide Treatment Of Neuroleptica-Related Prediabetes

    Not yet reported Jan Frystyk 154 participants Est. completion 2024-05-01 1 site
    Other conditions: Schizophrenia, Prediabetic State
    View official trial listing →
  • Enrolling by invitation NCT NCT05195944

    Semaglutide vs Sitagliptin

    Not yet reported University Health Network, Toronto 58 participants Est. completion 2026-12 1 site
    MASHMASLD Other conditions: Liver Transplant; Complications, Diabetes Mellitus
    View official trial listing →
  • Active, not recruiting NCT NCT05202353

    A Study in People With Obesity to Test the Effects of BI 456906 Compared With Semaglutide on Glucagon Receptor Activity in the Liver

    Not yet reported Boehringer Ingelheim 29 participants Est. completion 2027-02-03 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT05205928

    Weekly Subcutaneous Semaglutide as Adjunct to Closed-loop Therapy in Type 1 Diabetes Care

    Not yet reported, Not yet reported McGill University Health Centre/Research Institute of the McGill University Health Centre 28 participants Est. completion 2024-06-30 1 site
    Other conditions: Type 1 Diabetes, Diabetes Mellitus, Type 1
    View official trial listing →
  • Suspended NCT NCT05209165

    Semaglutide to Reduce Atrial Fibrillation Burden

    Not yet reported San Francisco Veterans Affairs Medical Center 132 participants Est. completion 2028-05 1 site Stand-alone
    Other conditions: Atrial Fibrillation, Obesity, Overweight
    View official trial listing →
  • Active, not recruiting NCT NCT05220917

    Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study

    Brigham and Women's Hospital 781430 participants Est. completion 2027-09-30 1 site
    Type 2 diabetes Other conditions: Cardiovascular Events, Renal Disease
    View official trial listing →
  • Completed NCT NCT05227196

    A Research Study Looking at the Comparability of 2 Different Forms of Oral Semaglutide in Healthy People

    Not yet reported Novo Nordisk A/S 546 participants Est. completion 2023-08-08 3 sites
    Type 2 diabetes Other conditions: Healthy Volunteers
    View official trial listing →
  • Completed NCT NCT05230589

    A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Saudi Arabia, as Part of Local Clinical Practice

    Novo Nordisk A/S 194 participants Est. completion 2023-03-13 2 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05230615

    A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Italy, as Part of Local Clinical Practice

    Novo Nordisk A/S 458 participants Est. completion 2023-10-31 2 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05232708

    A Clinical Trial Looking at the Comparability of 2 Different Forms of Semaglutide

    Not yet reported Novo Nordisk A/S 18 participants Est. completion 2022-08-30 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05236517

    A Research Study Looking at How 50 mg Semaglutide Daily Affects Food Intake and Emptying of the Stomach in People With Obesity

    Not yet reported Novo Nordisk A/S 60 participants Est. completion 2022-11-07 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Status unknown NCT NCT05249881

    "Efficacy of Once Weekly GLP 1 Analogue: Semaglutide. A Multicenter Experience From Pakistan."

    Not yet reported Aga Khan University 300 participants Est. completion 2022-12 2 sites
    Type 2 diabetes Other conditions: Weight Change, Body
    View official trial listing →
  • Active, not recruiting NCT NCT05254314

    Glucagon-Like Peptide-1 Receptor Agonist in the Treatment of Adult, Obesity-related, Symptomatic Asthma (GATA-3)

    Not yet reported Vanderbilt University Medical Center 100 participants Est. completion 2026-12 1 site Stand-alone
    Other conditions: Asthma
    View official trial listing →
  • Completed NCT NCT05259033

    A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People With Type 2 Diabetes Compared to Weekly Semaglutide (COMBINE 2)

    Not yet reported Novo Nordisk A/S 683 participants Est. completion 2024-01-16 193 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05302596

    Semaglutide Use in Elderly Obese Patients

    Not yet reported State University of New York at Buffalo 16 participants Est. completion 2024-10-30 1 site Stand-alone
    Other conditions: Obesity, Aging
    View official trial listing →
  • Completed NCT NCT05303857

    Analyse the Effect of Semaglutide on Vascular Structure and Function in Patients With Early Type 2 Diabetes

    Not yet reported University of Erlangen-Nürnberg Medical School 107 participants Est. completion 2025-04-17 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05316662

    A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Mexico, as Part of Local Clinical Practice

    Novo Nordisk A/S 187 participants Est. completion 2024-04-06 2 sites
    Type 2 diabetes
    View official trial listing →
  • Status unknown NCT NCT05322200

    The POST-ACS Study

    Not yet reported Swansea Bay University Health Board 140 participants Est. completion 2024-08-01 1 site
    Cardiovascular disease Other conditions: Diabetes Mellitus, Acute Coronary Syndrome
    View official trial listing →
  • Active, not recruiting NCT NCT05333003

    Semaglutide in Comorbid Schizophrenia Spectrum Disorder and Obesity

    Not yet reported Centre for Addiction and Mental Health 92 participants Est. completion 2026-08 1 site Stand-alone
    Other conditions: Schizophrenia Spectrum Disorders
    View official trial listing →
  • Completed NCT NCT05371496

    Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection Fraction

    Not yet reported Mayo Clinic 81 participants Est. completion 2026-07-17 1 site
    Heart failure Other conditions: Cardiomyopathy, Obesity
    View official trial listing →
  • Completed NCT NCT05390307

    Obesity Treatment to Improve Diabetes

    Not yet reported Dasman Diabetes Institute 60 participants Est. completion 2024-01-01 1 site
    Other conditions: Type 1 Diabetes
    View official trial listing →
  • Completed NCT NCT05394519

    A Research Study to See How Well CagriSema Helps People With Type 2 Diabetes and Excess Body Weight Lose Weight

    Not yet reported Novo Nordisk A/S 1200 participants Est. completion 2025-02-03 179 sites Stand-alone
    Type 2 diabetes Other conditions: Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT05429593

    A Research Study Investigating How Semaglutide and Dapagliflozin Act in Your Body When Dosed in One Tablet

    Not yet reported Novo Nordisk A/S 152 participants Est. completion 2023-04-13 2 sites Stand-alone
    Other conditions: Healthy Volunteers
    View official trial listing →
  • Completed NCT NCT05435677

    A Research Study to Look at How Insulin Icodec and Semaglutide Work in the Body of People From China With Type 2 Diabetes When Given Alone or Together

    Not yet reported Novo Nordisk A/S 20 participants Est. completion 2023-04-25 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Active, not recruiting NCT NCT05441267

    A Study of Cardiovascular Events iN Diabetes Plus

    Not yet reported University of Oxford 21296 participants Est. completion 2048-08-17 1 site
    Type 2 diabetes
    View official trial listing →
  • Status unknown NCT NCT05442450

    Efficacy of Oral Semaglutide in Overweight or Obesity

    Not yet reported Asian Institute of Gastroenterology, India 116 participants Est. completion 2023-06-30 1 site Stand-alone
    Other conditions: Obesity, Weight Loss
    View official trial listing →
  • Completed NCT NCT05443191

    A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Finland, as Part of Local Clinical Practice

    Novo Nordisk A/S 50 participants Est. completion 2023-04-27 3 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05443334

    A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Spain, as Part of Local Clinical Practice

    Novo Nordisk A/S 465 participants Est. completion 2024-07-04 2 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05443568

    A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Israel, as Part of Local Clinical Practice

    Novo Nordisk A/S 155 participants Est. completion 2024-11-16 1 site
    Type 2 diabetes
    View official trial listing →
  • Withdrawn NCT NCT05444153

    Research Study to Compare Semaglutide Tablets With Empagliflozin Tablets Taken Once Daily in People With Type 2 Diabetes and Obesity

    Not yet reported Novo Nordisk A/S Est. completion 2025-08-29 Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05468632

    A Study in North Macedonia Investigating Retrospective Data of Glucagon-like Peptide-1 (GLP-1) Participants With Type 2 Diabetes (T2D) in Real World Environment (RWE) Setting (MIRAGE)

    Novo Nordisk A/S 314 participants Est. completion 2022-07-31 17 sites
    Type 2 diabetes
    View official trial listing →
  • Withdrawn NCT NCT05473286

    A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Germany, as Part of Local Clinical Practice

    Novo Nordisk A/S Est. completion 2024-05-16
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05478252

    A Research Study to Compare Two Semaglutide Medicines in People With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 388 participants Est. completion 2023-09-18 104 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05486065

    A Research Study to Look Into How Well Semaglutide Medicine Works at Different Doses in People With Type 2 Diabetes and Overweight

    Not yet reported Novo Nordisk A/S 245 participants Est. completion 2023-12-13 130 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Status unknown NCT NCT05492305

    Glucagon-like Peptide 1 (GLP1) Receptor Agonists and Mental Health

    King's College London 20 participants Est. completion 2023-08 1 site
    Other conditions: Diabetes Mellitus, Obesity, Mental Health Issue
    View official trial listing →
  • Completed NCT NCT05498610

    A Research Study of How the Medicine NNC0480-0389 Taken With Semaglutide Works in the Body of Healthy Chinese Men

    Not yet reported Novo Nordisk A/S 24 participants Est. completion 2022-10-12 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05502562

    A Research Study to Understand How Oral Semaglutide Works in People With Type 2 Diabetes in India

    Novo Nordisk A/S 388 participants Est. completion 2024-06-03
    Type 2 diabetes
    View official trial listing →
  • Enrolling by invitation NCT NCT05503927

    A Study to Evaluate the Safety of Exposure to Wegovy During Pregnancy

    Novo Nordisk A/S 2701 participants Est. completion 2027-08-15 2 sites
    Other conditions: Pregnancy, Obesity, Overweight
    View official trial listing →
  • Completed NCT NCT05514535

    A Research Study to Look Into How Semaglutide, Together With a Lower Dose of Insulin Glargine, Compares to a Higher Dose of Insulin Glargine Alone in People With Type 2 Diabetes (SUSTAIN OPTIMIZE)

    Not yet reported Novo Nordisk A/S 573 participants Est. completion 2025-04-09 239 sites Stand-alone
    Type 2 diabetes Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT05520775

    Semaglutide for Alcohol Use Disorder

    Not yet reported University of North Carolina, Chapel Hill 48 participants Est. completion 2024-04-19 1 site Stand-alone
    Alcohol use disorder Other conditions: Cigarette Smoking
    View official trial listing →
  • Completed NCT NCT05530577

    Effects of Semaglutide on Nicotine Intake

    Not yet reported University of North Carolina, Chapel Hill 24 participants Est. completion 2024-05-13 1 site Stand-alone
    Other conditions: Tobacco Use Disorder, Nicotine Addiction
    View official trial listing →
  • Completed NCT NCT05537233

    ADJUnct Semaglutide Treatment in Type 1 Diabetes

    Not yet reported Viral N. Shah 115 participants Est. completion 2024-08-06 4 sites Stand-alone
    Other conditions: Type 1 Diabetes, Obesity
    View official trial listing →
  • Completed NCT NCT05548647

    Semaglutide Treatment, Appetite, and Eating Behavior: Long-term Effects

    Not yet reported University of Pennsylvania 120 participants Est. completion 2025-05-12 1 site
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT05564117

    Research Study Looking at How Well Semaglutide Tablets Taken Once Daily Work in People Who Have a Body Weight Above the Healthy Range

    Not yet reported Novo Nordisk A/S 307 participants Est. completion 2024-05-07 23 sites Stand-alone
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Active, not recruiting NCT NCT05567796

    A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight

    Not yet reported Novo Nordisk A/S 3400 participants Est. completion 2026-10-19 256 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT05574439

    Young Adults With Early-onset Obesity Treated With Semaglutide

    Not yet reported Signe Torekov 246 participants Est. completion 2026-04-01 2 sites
    Other conditions: Obesity, Adolescent
    View official trial listing →
  • Completed NCT NCT05579249

    A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in America

    Not yet reported Novo Nordisk A/S 500 participants Est. completion 2024-11-27 1 site
    Other conditions: Obesity
    View official trial listing →
  • Terminated NCT NCT05579977

    Trial to Learn About the Study Medicine (PF-07081532) and Rybelsus in People With Type 2 Diabetes and Separately PF-07081532 in People With Obesity

    Not yet reported Pfizer 902 participants Est. completion 2023-09-22 90 sites
    Other conditions: Diabetes Mellitus, Obesity
    View official trial listing →
  • Status unknown NCT NCT05597202

    Does the Hematopoietic Stem Cell Govern Residual Inflammatory Cardiovascular Risk in Type 2 Diabetes

    Not yet reported Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) 22 participants Est. completion 2024-04 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05616013

    Safety and Efficacy of Bimagrumab and Semaglutide in Adults Who Are Overweight or Obese

    Not yet reported Eli Lilly and Company 507 participants Est. completion 2025-06-14 26 sites Stand-alone
    Other conditions: Obesity, Obese, Overweight or Obesity
    View official trial listing →
  • Status unknown NCT NCT05616052

    Comparison of Body Weight Change Through Different Smeglutide Administration Methods

    Not yet reported Huashan Hospital 80 participants Est. completion 2023-12-01 1 site
    Other conditions: Weight Change, Body
    View official trial listing →
  • Active, not recruiting NCT NCT05622045

    Does Personality Predict Patient Adherence, Health Behaviors, and Weight Loss Outcomes During the Latino Crossover Semaglutide Study (LCSS)? (Story-LCSS Project)

    Loma Linda University 59 participants Est. completion 2027-05 1 site
    Other conditions: Obesity, Body Weight Changes
    View official trial listing →
  • Status unknown NCT NCT05646199

    Semaglutide vs Metformin in Polycystic Ovary Syndrome (PCOS)

    Not yet reported, Not yet reported University of Hull 60 participants Est. completion 2025-12-30 1 site
    Other conditions: Polycystic Ovary Syndrome
    View official trial listing →
  • Completed NCT NCT05646706

    A Research Study to See How Semaglutide Helps People With Excess Weight, Lose Weight (STEP UP)

    Not yet reported Novo Nordisk A/S 1407 participants Est. completion 2024-11-26 107 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT05649137

    A Research Study to See How Semaglutide Helps People With Excess Weight and Type 2 Diabetes Lose Weight

    Not yet reported Novo Nordisk A/S 512 participants Est. completion 2024-12-13 76 sites Stand-alone
    Type 2 diabetes Other conditions: Obesity
    View official trial listing →
  • Active, not recruiting NCT NCT05669755

    REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels

    Not yet reported Novo Nordisk A/S 7101 participants Est. completion 2027-10-14 633 sites
    Cardiovascular disease
    View official trial listing →
  • Completed NCT NCT05670379

    Assessment of Safety, Tolerability and Drug Levels of Exenatide Implant

    Not yet reported Vivani Medical, Inc 24 participants Est. completion 2025-08-21 1 site
    Other conditions: Overweight and Obesity, Type2diabetes
    View official trial listing →
  • Terminated NCT NCT05671653

    A Study to Evaluate the Effect of the Experimental GLP-1 Drug PF-07081532 on Blood Levels of Common Birth Control Pills, and Drugs Omeprazole and Midazolam, and Effect of GLP-1 Drug Semaglutide on Midazolam Blood Levels in Healthy Adults With Weight in the Obesity Range

    Not yet reported Pfizer 32 participants Est. completion 2023-11-03 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT05689099

    A Research Trial Looking at the Comparability of 2 Different Concentrations of Semaglutide for the 0.5 Milligram (mg) Dose

    Not yet reported Novo Nordisk A/S 20 participants Est. completion 2023-05-30 1 site Stand-alone
    Type 2 diabetes Other conditions: Healthy Participants
    View official trial listing →
  • Enrolling by invitation NCT NCT05689372

    Regulatory Post Marketing Surveillance (rPMS) Study of Ozempic (Semaglutide) to Evaluate Safety and Effectiveness in Patients With Type 2 Diabetes Mellitus in Routine Clinical Practice in Korea

    Novo Nordisk A/S 600 participants Est. completion 2027-05-31 1 site
    Type 2 diabetes
    View official trial listing →
  • Status unknown NCT NCT05702905

    Semaglutide Improves Metabolic Abnormalities and Fertility in Obese Infertile Women With Polycystic Ovary Syndrome

    Not yet reported Peking University First Hospital 75 participants Est. completion 2025-06-30 1 site
    Other conditions: PCOS (Polycystic Ovary Syndrome), Semaglutide
    View official trial listing →
  • Not yet recruiting NCT NCT05714683

    Regulatory Post Marketing Surveillance (rPMS) Study of Rybelsus (Oral Semaglutide) to Evaluate Safety and Effectiveness in Patients With Type 2 Diabetes Mellitus in Routine Clinical Practice in Korea

    Novo Nordisk A/S 600 participants Est. completion 2026-10-30
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05716724

    O-SEMA-Fast: A Research Study to Understand How Oral Semaglutide Works in People With Type 2 Diabetes Who Plan to Fast During Ramadan in the United Arab Emirates, Saudi Arabia, and Kuwait

    Novo Nordisk A/S 288 participants Est. completion 2023-07-09 20 sites
    Type 2 diabetes
    View official trial listing →
  • Active, not recruiting NCT NCT05726227

    A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight

    Not yet reported Novo Nordisk A/S 210 participants Est. completion 2026-12-07 56 sites
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT05751226

    A Study in People With Overweight or Obesity to Test How Well Different Doses of BI 1820237 Are Tolerated When Given Alone or in Combination With Either Semaglutide or BI 456906

    Not yet reported Boehringer Ingelheim 88 participants Est. completion 2024-08-01 1 site Stand-alone
    Other conditions: Healthy, Obesity
    View official trial listing →
  • Status unknown NCT NCT05751720

    Effect on Non-Alcoholic Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus With Gastric Inhibitory Polypeptide/Glucagon Like Peptide-1 Analogue

    Not yet reported, Not yet reported Dr Adnan Agha 30 participants Est. completion 2025-02 1 site
    Type 2 diabetes Other conditions: Non-Alcoholic Fatty Liver Disease, Non-alcoholic Steatohepatitis, Liver Fat
    View official trial listing →
  • Completed NCT NCT05755360

    DOORS: A Research Study to Understand How Oral Semaglutide Works in People With Type 2 Diabetes Who Change From Dipeptidyl Peptidase-4 Inhibitor (DPP4i) Treatment to Oral Semaglutide in Italy

    Novo Nordisk A/S 291 participants Est. completion 2024-10-21 25 sites
    Type 2 diabetes
    View official trial listing →
  • Active, not recruiting NCT NCT05756764

    Anti-obesity Pharmacotherapy and Inflammation

    Louisiana State University Health Sciences Center in New Orleans 30 participants Est. completion 2026-02-20 2 sites
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT05766709

    A Research Study Comparing Blood Levels of Medicines NNC0194-0499 and Semaglutide Administered as a Combination Formulation Versus Two Separate Formulations

    Not yet reported Novo Nordisk A/S 53 participants Est. completion 2024-02-09 1 site Stand-alone
    Other conditions: Non-alcoholic Steatohepatitis
    View official trial listing →
  • Completed NCT NCT05768945

    Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Semaglutide v DPP4 Inhibitors

    Brigham and Women's Hospital 742670 participants Est. completion 2023-12-31 1 site
    Other conditions: Diabetes
    View official trial listing →
  • Status unknown NCT NCT05779644

    Effects of GLP-1RA on Body Weight, Metabolism and Fat Distribution in Overweight/Obese Patients With Type 2 Diabetes Mellitus

    Not yet reported RenJi Hospital 300 participants Est. completion 2025-02-23 1 site Stand-alone
    Type 2 diabetes Other conditions: Metformin, Obesity, Abdominal, Abdominal Fat, Non-Alcoholic Fatty Liver Disease, Metabolism Disorder, Glucose, Metabolism Disorder, Lipid
    View official trial listing →
  • Completed NCT NCT05784402

    A Research Study to Compare How Much Semaglutide is Found in the Blood With Different Tablets of Oral Semaglutide in Healthy Participants

    Not yet reported Novo Nordisk A/S 264 participants Est. completion 2024-03-29 3 sites Stand-alone
    Other conditions: Healthy Participants
    View official trial listing →
  • Completed NCT NCT05786521

    Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults

    Not yet reported The University of Texas Health Science Center at San Antonio 20 participants Est. completion 2024-05-20 1 site Stand-alone
    Type 2 diabetesPrediabetes Other conditions: Aging, Overweight and Obesity
    View official trial listing →
  • Completed NCT NCT05788965

    Semaglutide in CFRD

    Not yet reported, Not yet reported University of Minnesota 8 participants Est. completion 2024-12-31 1 site
    Other conditions: Cystic Fibrosis, Cystic Fibrosis-related Diabetes
    View official trial listing →
  • Withdrawn NCT NCT05812183

    Gastric Sleeve-Induced Weight Loss on Shortness of Breath in Obesity

    Not yet reported University of California, Los Angeles Est. completion 2025-02-12 Stand-alone
    Other conditions: Dyspnea, Quality of Life
    View official trial listing →
  • Completed NCT NCT05813249

    Semaglutide in Nonalcoholic Fatty Liver Disease

    Not yet reported Zagazig University 180 participants Est. completion 2024-04-01 1 site
    Other conditions: Non-alcoholic Fatty Liver Disease
    View official trial listing →
  • Completed NCT NCT05813912

    A Research Study to See How a New Weekly Insulin, Insulin Icodec When Given Along With Semaglutide Helps in Reducing the Blood Sugar Level in Patients With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 148 participants Est. completion 2025-05-16 39 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05813925

    A Research Study to See How Well CagriSema Helps People in East Asia With Excess Body Weight Lose Weight

    Not yet reported Novo Nordisk A/S 331 participants Est. completion 2025-03-07 28 sites Stand-alone
    Other conditions: Obesity or Overweight
    View official trial listing →
  • Completed NCT NCT05816057

    A Study of the Efficacy and Safety of Semaglutide Injection in the Treatment of Type 2 Diabetes Mellitus

    Not yet reported Hangzhou Jiuyuan Gene Engineering Co. Ltd., 476 participants Est. completion 2023-10-31 35 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05822830

    A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities

    Not yet reported Eli Lilly and Company 751 participants Est. completion 2024-11-13 32 sites
    Other conditions: Obesity, Overweight
    View official trial listing →
  • Withdrawn NCT NCT05829460

    Primary Prevention and Uterine Preservation in Premenopausal Women With Obesity and Endometrial Hyperplasia

    Not yet reported Washington University School of Medicine Est. completion 2032-04-30 Stand-alone
    Other conditions: Endometrial Hyperplasia
    View official trial listing →
  • Completed NCT NCT05857085

    Novel Therapeutics and Endothelial Dysfunction in T1DM Patients

    Not yet reported General and Teaching Hospital Celje 90 participants Est. completion 2023-04-20 1 site
    Other conditions: Endothelial Dysfunction, Diabetes Mellitus, Type 1, Biomarkers, Endothelial Progenitor Cells, SGLT 2 Inhibitors, Incretins, Glucose Excursions, FMD, FPF, Arterial Stiffness
    View official trial listing →
  • Enrolling by invitation NCT NCT05872022

    A Study to Evaluate Safety of Exposure to Wegovy During Pregnancy

    Novo Nordisk A/S 728 participants Est. completion 2032-12-30 3 sites
    Other conditions: Pregnancy, Obesity, Overweight
    View official trial listing →
  • Completed NCT NCT05877547

    A Clinical Study of Efinopegdutide in Participants With Precirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-6024-013)

    Not yet reported Merck Sharp & Dohme LLC 381 participants Est. completion 2025-12-29 175 sites
    MASLDMASH Other conditions: Non-alcoholic Fatty Liver Disease, Fatty Liver, Nonalcoholic
    View official trial listing →
  • Completed NCT NCT05890976

    Research Study Looking at How Well Semaglutide Tablets Taken Once Daily Work in Chinese Adults Who Are Above a Healthy Weight Range (OASIS 3)

    Not yet reported Novo Nordisk A/S 200 participants Est. completion 2025-01-16 16 sites
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT05891496

    A Research Study Looking at the Effect of Semaglutide on the Immune System and Other Biological Processes in People With Alzheimer's Disease

    Not yet reported Novo Nordisk A/S 23 participants Est. completion 2025-09-08 12 sites Stand-alone
    Other conditions: Alzheimers Disease
    View official trial listing →
  • Completed NCT NCT05891587

    Semaglutide Therapy for Alcohol Reduction - Tulsa

    Not yet reported Oklahoma State University Center for Health Sciences 80 participants Est. completion 2025-10-01 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT05895643

    Does Semaglutide Reduce Alcohol Intake in Patients With Alcohol Use Disorder and Comorbid Obesity?

    Not yet reported Psychiatric Centre Rigshospitalet 108 participants Est. completion 2025-07-31 1 site Stand-alone
    Alcohol use disorder Other conditions: Alcohol Abuse, Alcohol Addiction
    View official trial listing →
  • Terminated NCT NCT05897372

    Feasibility of Aggressive Albuminuria Reduction in Biopsy-Proven Diabetic Nephropathy - a Pilot Study

    Not yet reported Iain Bressendorff 1 participants Est. completion 2024-09-23 1 site
    Chronic kidney disease
    View official trial listing →
  • Completed NCT NCT05897398

    SEMASEARCH, Retrospective/Prospective Cohort Nested at ATUc/AP2 WEGOVY®

    Hospices Civils de Lyon 1100 participants Est. completion 2025-06-10 14 sites
    Other conditions: Obesity, Bariatric Surgery, Binge Eating Disorder, Syndromic Obesity, Sarcopenic Obesity, Iatrogenic Obesity, Psychotropic Drugs
    View official trial listing →
  • Completed NCT NCT05920889

    Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke Treated by Reperfusion Therapies

    Not yet reported Chinese University of Hong Kong 140 participants Est. completion 2024-10-25 2 sites
    Cardiovascular disease Other conditions: Brain Diseases
    View official trial listing →
  • Status unknown NCT NCT05950516

    Efficacy and Safety of Semaglutide Ingection in Subjects With Type 2 Diabetes

    Not yet reported Qilu Pharmaceutical Co., Ltd. 478 participants Est. completion 2025-01-22 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05984238

    A Trial to Evaluate Safety, Feasibility and Efficacy of Endoscopic Duodenal PEF Therapy

    Not yet reported Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) 33 participants Est. completion 2026-05-28 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT05996848

    A Research Study to See How Well CagriSema Helps People in China With Excess Body Weight Lose Weight

    Not yet reported Novo Nordisk A/S 300 participants Est. completion 2025-02-22 37 sites Stand-alone
    Other conditions: Obesity or Overweight
    View official trial listing →
  • Completed NCT NCT05996874

    A Research Study Comparing the Effect of Different Dosing Conditions on Blood Levels of Semaglutide in a New Tablet Composition in Healthy Participants

    Not yet reported Novo Nordisk A/S 121 participants Est. completion 2024-04-18 1 site Stand-alone
    Other conditions: Healthy Participants
    View official trial listing →
  • Active, not recruiting NCT NCT06005012

    Semaglutide Treatment in the Real-world for Fibrosis Due to NAFLD in Obesity and T2DM

    Not yet reported University of California, San Diego 120 participants Est. completion 2026-12-31 1 site Stand-alone
    Type 2 diabetes Other conditions: Fibrosis, Liver, Non-Alcoholic Fatty Liver Disease
    View official trial listing →
  • Completed NCT NCT06027567

    The Effect of an Anti-obesity Drug, Semaglutide, as Treatment in New-onset Idiopathic Intracranial Hypertension (IIH) Compared to Standard Weight Management (Dietician) With Regards to Change in Weight and Intracranial Pressure

    Not yet reported Rigmor Højland Jensen 38 participants Est. completion 2025-10-28 2 sites Stand-alone
    Other conditions: Idiopathic Intracranial Hypertension, Intracranial Pressure, Obesity, Pseudotumor Cerebri Syndrome, Papilledema, Weight Loss
    View official trial listing →
  • Completed NCT NCT06041217

    A Research Study to See How Well Semaglutide Helps People Who Have a Body Weight Above the Healthy Weight Range

    Not yet reported Novo Nordisk A/S 242 participants Est. completion 2025-05-07 21 sites Stand-alone
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Active, not recruiting NCT NCT06042153

    DIALYSIS-TIR Study

    Not yet reported University of Texas Southwestern Medical Center 43 participants Est. completion 2028-09 5 sites Stand-alone
    Type 2 diabetes Other conditions: End Stage Renal Disease on Dialysis
    View official trial listing →
  • Completed NCT NCT06045221

    A Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With Metformin

    Not yet reported Eli Lilly and Company 1698 participants Est. completion 2025-08-22 131 sites
    Type 2 diabetes
    View official trial listing →
  • Active, not recruiting NCT NCT06050577

    The Effect of Oral Semaglutide on Bone Turnover in Patients With T2D: a Randomized Placebo-controlled Clinical Trial

    Not yet reported Odense University Hospital 64 participants Est. completion 2027-01-15 1 site Stand-alone
    Type 2 diabetes Other conditions: Osteopenia
    View official trial listing →
  • Status unknown NCT NCT06057077

    Semaglutide GLP1 Agonists With Degludec Basal-bolus Insulin in Early Type 1 Diabetes to Basal-bolus

    Not yet reported, Not yet reported Ministry of Health, Saudi Arabia 120 participants Est. completion 2024-12-31
    Other conditions: Type 1 Diabetes
    View official trial listing →
  • Completed NCT NCT06065540

    A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor

    Not yet reported Novo Nordisk A/S 2734 participants Est. completion 2026-01-06 405 sites
    Type 2 diabetes
    View official trial listing →
  • Withdrawn NCT NCT06083675

    Research Study to Compare Semaglutide Tablets With Empagliflozin or Metformin Tablets in People With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S Est. completion 2027-05-28 100 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT06097390

    A Research Study Looking at New Protein-based Tablets in Healthy Men - Oral Formulation III

    Not yet reported Novo Nordisk A/S 121 participants Est. completion 2024-03-27 1 site Stand-alone
    Other conditions: Healthy Participants
    View official trial listing →
  • Completed NCT NCT06118008

    A Study of HS-20094 in T2DM Participants

    Not yet reported Jiangsu Hansoh Pharmaceutical Co., Ltd. 54 participants Est. completion 2024-01-04 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT06118203

    Semaglutide Use in Acute Pulmonary Embolism

    Imperial College London 18 participants Est. completion 2023-03-05 1 site
    Other conditions: Pulmonary Embolism
    View official trial listing →
  • Completed NCT NCT06120556

    Efficacy of Glucagon-like Peptide-1 Receptor Agonists According to Type 2 Diabetes Subtypes

    Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari 130 participants Est. completion 2023-10-31 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT06131372

    A Research Study to See if Kidney Damage in People With Chronic Kidney Disease and Type 2 Diabetes Living With Overweight or Obesity Can be Reduced by CagriSema Compared to Semaglutide, Cagrilintide and Placebo

    Not yet reported Novo Nordisk A/S 626 participants Est. completion 2025-11-06 128 sites
    Chronic kidney diseaseType 2 diabetes Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT06131437

    A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose Weight

    Not yet reported Novo Nordisk A/S 809 participants Est. completion 2026-01-09 46 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT06154486

    Evaluation of Gastric Content of Volunteers Fasting and Using Semaglutide: an Observational and Cross-sectional Study

    Hospital Israelita Albert Einstein 30 participants Est. completion 2023-08-22 1 site
    Other conditions: Pneumonia, Aspiration, Anesthesia
    View official trial listing →
  • Completed NCT NCT06161844

    Efficacy and Safety of Semaglutide Injection (HD1916) in Patients With Type 2 Diabetes Mellitus

    Not yet reported CSPC ZhongQi Pharmaceutical Technology Co., Ltd. 506 participants Est. completion 2025-05-14 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Status unknown NCT NCT06182618

    Retrospective Analysis for Patients With Metabolic Syndrome

    Second Affiliated Hospital, Zhejiang University, School of Medicine 400 participants Est. completion 2024-01-01 1 site
    Metabolic syndrome
    View official trial listing →
  • Completed NCT NCT06215196

    Effectiveness and Safety of Semaglutide Combined With Dietary Fiber (Soloways) in Adults With Overweight or Obesity

    Not yet reported S.LAB (SOLOWAYS) 81 participants Est. completion 2023-08-20 1 site Stand-alone
    Other conditions: Overweight and Obesity
    View official trial listing →
  • Completed NCT NCT06221696

    Preventing Weight Regain Post-Semaglutide Treatment With Active Fiber Supplement (Soloways)

    Not yet reported S.LAB (SOLOWAYS) 160 participants Est. completion 2023-12-01 1 site
    Other conditions: Overweight and Obesity
    View official trial listing →
  • Completed NCT NCT06221969

    A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor

    Not yet reported Novo Nordisk A/S 1024 participants Est. completion 2026-04-06 197 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Withdrawn NCT NCT06222437

    Semaglutide and Polycystic Ovarian Syndrome: an Emerging Treatment Strategy

    Not yet reported Methodist Health System Est. completion 2027-02 Stand-alone
    Other conditions: Polycystic Ovary Syndrome
    View official trial listing →
  • Active, not recruiting NCT NCT06234111

    Semaglutide and Physical Activity for Obesity and Multimorbidity

    Hvidovre University Hospital 35 participants Est. completion 2026-11 1 site
    Other conditions: Obesity Morbid, Multimorbidity, Obesity
    View official trial listing →
  • Status unknown NCT NCT06243536

    The Effect of Semaglutide on Disordered Eating Behaviour in Type 2 Diabetic Patients

    Not yet reported University Hospital Sestre Milosrdnice 60 participants Est. completion 2024-12-31 1 site
    Type 2 diabetes Other conditions: Overweight, Disordered Eating Behaviors
    View official trial listing →
  • Status unknown NCT NCT06256549

    A Study of GZR18 Injection in Chinese Patients With Type 2 Diabetes Mellitus

    Not yet reported Gan and Lee Pharmaceuticals, USA 272 participants Est. completion 2024-07-20 1 site
    Type 2 diabetes
    View official trial listing →
  • Active, not recruiting NCT NCT06260722

    Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)

    Not yet reported Eli Lilly and Company 1250 participants Est. completion 2027-01 77 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT06263595

    Semaglutide and Preoperative Residual Gastric Volumes

    University of Calgary 94 participants Est. completion 2025-05-16 1 site
    Other conditions: Pulmonary Aspiration
    View official trial listing →
  • Completed NCT NCT06267092

    A Study of How CagriSema Works on Appetite in People With Excess Body Weight

    Not yet reported Novo Nordisk A/S 164 participants Est. completion 2025-12-08 1 site Stand-alone
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT06269107

    A Research Study to See How Well New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Levels in People With Type 2 Diabetes (T2D), Compared to Daily Insulin Glargine (COMBINE 4)

    Not yet reported Novo Nordisk A/S 485 participants Est. completion 2025-07-08 118 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT06269120

    SEMA-CardioDiab HUNGARY: A Research Study to Understand the Effects of Oral Semaglutide on Blood Sugar Levels, Weight, and Cardiovascular Risk in People With Type 2 Diabetes Patients in Hungary

    Novo Nordisk A/S 243 participants Est. completion 2026-05-05 19 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT06282458

    Dose-Finding Study Evaluating Effect on Body Composition of Enobosarm in Patients Taking a GLP-1 for Chronic Weight Mgmt

    Not yet reported Veru Inc. 168 participants Est. completion 2025-08-22 14 sites
    Other conditions: Muscle Loss, Obesity
    View official trial listing →
  • Active, not recruiting NCT NCT06283667

    Special Use - Results Surveillance on Long-term Use With Wegovy®

    Novo Nordisk A/S 1071 participants Est. completion 2028-01-31 112 sites
    Other conditions: Obesity
    View official trial listing →
  • Not yet recruiting NCT NCT06287307

    Semaglutide 2.4mg for Low Responders After Bariatric Surgery

    Not yet reported Zuyderland Medisch Centrum 152 participants Est. completion 2026-09
    Other conditions: Obesity, Obesity, Morbid, Weight Gain
    View official trial listing →
  • Completed NCT NCT06289504

    A Study on How CagriSema Affects Levels of Atorvastatin and Warfarin in the Blood of Participants With Excess Body Weight

    Not yet reported Novo Nordisk A/S 34 participants Est. completion 2024-11-15 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT06292065

    Gastric Ultrasound To Assess Gastric Contents In Patients On Semaglutide Therapy

    Not yet reported Nils Vlaeminck 88 participants Est. completion 2025-05-31 1 site
    Other conditions: Gastroparesis
    View official trial listing →
  • Active, not recruiting NCT NCT06299098

    A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weight Loss, Fat Loss, and Lean Mass Preservation

    Not yet reported Regeneron Pharmaceuticals 1005 participants Est. completion 2026-10-21 60 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Status unknown NCT NCT06301191

    The Effect of Semaglutide on Cardiovascular Markers and Liver Function

    Attikon Hospital 50 participants Est. completion 2024-05-01 1 site
    Other conditions: Diabetes Type 2
    View official trial listing →
  • Completed NCT NCT06323161

    A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Once-daily Basal Insulin With or Without Metformin

    Not yet reported Novo Nordisk A/S 274 participants Est. completion 2025-10-23 61 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT06323174

    A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Diet and Exercise

    Not yet reported Novo Nordisk A/S 189 participants Est. completion 2025-12-22 50 sites
    Type 2 diabetes
    View official trial listing →
  • Terminated NCT NCT06333080

    The Effect of Adherence to Oral Semaglutide on Glycaemic Control in People With Type 2 Diabetes Treated With Metformin

    Aalborg University Hospital 1 participants Est. completion 2025-07-29 1 site
    Type 2 diabetes
    View official trial listing →
  • Status unknown NCT NCT06339086

    Efficacy and Safety of Semaglutide Injection in Subjects With Type 2 Diabetes

    Not yet reported Chengdu Brilliant Pharmaceutical Co., Ltd. 478 participants Est. completion 2025-12-30 Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Status unknown NCT NCT06344247

    Comparison of the Efficacy and Safety of SGLT2i and GLP-1 Receptor Agonists in Obese Patients With Kidney Disease

    Not yet reported RenJi Hospital 48 participants Est. completion 2025-12-01 1 site Stand-alone
    Chronic kidney disease Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT06351748

    Real-world Study of CHina Ozempic cLinicAl pRactice in Patients With Type 2 Diabetes (SCHOLAR)

    Novo Nordisk A/S 34238 participants Est. completion 2024-03-29 1 site
    Type 2 diabetes
    View official trial listing →
  • Withdrawn NCT NCT06354101

    The Purpose of This Registry Study is to Learn More About Metabolic Health: Approximately 15,000 Participants Who Are Overweight or Have Obesity With or Without Metabolic Diseases Are Expected to Participate in This Registry Study.

    CorEvitas Est. completion 2023-07-01
    Other conditions: Metabolic Health
    View official trial listing →
  • Status unknown NCT NCT06361823

    Exploratory Study on the Efficacy and Safety of Semaglutide for Idiopathic Intracranial Hypertension Treatment

    Not yet reported Capital Medical University 74 participants Est. completion 2025-01-01 Stand-alone
    Other conditions: Idiopathic Intracranial Hypertension
    View official trial listing →
  • Completed NCT NCT06363487

    Semaglutide and Cognition in Healthy Volunteers

    Not yet reported University of Oxford 70 participants Est. completion 2024-12-11 1 site
    Other conditions: Cognitive Change
    View official trial listing →
  • Completed NCT NCT06388187

    A Research Study to See How Well Different Doses of CagriSema Help People With Excess Body Weight Lose Weight

    Not yet reported Novo Nordisk A/S 300 participants Est. completion 2026-04-22 25 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT06390501

    The Effect of Weekly Semaglutide Treatment on Energy Expenditure

    Not yet reported Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences 60 participants Est. completion 2025-09-15 1 site Stand-alone
    Other conditions: Obesity; Drug
    View official trial listing →
  • Completed NCT NCT06400615

    Study That Tests AD109 in Patients Taking GLP-1 Drugs

    Not yet reported Apnimed 40 participants Est. completion 2024-12-26 4 sites
    Obstructive sleep apnea
    View official trial listing →
  • Completed NCT NCT06401746

    Body Surface Gastric Mapping in Patients on Semaglutide

    University of Western Sydney 9 participants Est. completion 2025-06-01 1 site
    Other conditions: Semaglutide-Induced Gastric Motility, Gastroparesis
    View official trial listing →
  • Completed NCT NCT06409130

    Effects of NNC0194-0499, Cagrilintide, and Semaglutide Alone or in Combinations on Liver Damage and Alcohol Use in People With Alcohol-related Liver Disease

    Not yet reported Novo Nordisk A/S 270 participants Est. completion 2026-01-12 102 sites Stand-alone
    Other conditions: Alcohol-related Liver Disease
    View official trial listing →
  • Active, not recruiting NCT NCT06420739

    The Semaglutide Study

    University Health Network, Toronto 100 participants Est. completion 2026-03-31 1 site
    Other conditions: Fasting
    View official trial listing →
  • Status unknown NCT NCT06422624

    A Study to Evaluate Safety, Tolerability and pK of Semaglutide ER Injectable Suspension in Healthy, Adult Human Subjects

    Not yet reported Bostal Drug Delivery Co., Ltd 14 participants Est. completion 2024-11 Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Status unknown NCT NCT06426446

    Monitoring Patients With Severe Obesity Treated With Wegovy® Using Connected Device: Real-world Data

    Not yet reported Assistance Publique - Hôpitaux de Paris 80 participants Est. completion 2025-06-01 1 site
    Other conditions: Obesity
    View official trial listing →
  • Status unknown NCT NCT06449235

    Real-World Evaluation of Omarigliptin for Type 2 Diabetes Meliitus in Bangladesh

    Not yet reported Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders 938 participants Est. completion 2025-06 1 site
    Other conditions: Type2diabetes
    View official trial listing →
  • Not yet recruiting NCT NCT06449625

    Semaglutide in Auto-HSCT

    Not yet reported Klaus Gottlob Müller 40 participants Est. completion 2027-02-01
    Other conditions: Intestinal Mucositis, Inflammation, Chemotherapeutic Toxicity
    View official trial listing →
  • Active, not recruiting NCT NCT06467604

    CRAVE Study: Comparing Craving Responses and Diet Quality of GLP1 Receptor Agonist Users

    University of California, Davis 7 participants Est. completion 2027-04-01 1 site
    Other conditions: Obesity
    View official trial listing →
  • Withdrawn NCT NCT06468748

    The Effects of Semaglutide on Body Composition and Performance in Military Personnel

    Not yet reported United States Army Research Institute of Environmental Medicine Est. completion 2025-03-27 1 site
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT06475586

    Effect of Semaglutide on the Psoriatic Lesions in Patients With Type 2 Diabetes Mellitus

    Not yet reported University of Banja Luka 30 participants Est. completion 2024-06-10 1 site Stand-alone
    Other conditions: Psoriasis Vulgaris, Diabetes Type 2
    View official trial listing →
  • Completed NCT NCT06478550

    A Research Study to Understand How People With Type 2 Diabetes Take Ozempic® and if the Ozempic®App Helps Them Stay on This Treatment

    Novo Nordisk A/S 304 participants Est. completion 2025-04-23 6 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT06489457

    The Effects of Semaglutide vs Testosterone Replacement Therapy on Functional Hypogonadism and Sperm Quality in Men With Type 2 Diabetes Mellitus and Obesity

    Not yet reported University Medical Centre Ljubljana 25 participants Est. completion 2023-06-30 1 site Stand-alone
    Type 2 diabetes Other conditions: Obesity, Functional Hypogonadism
    View official trial listing →
  • Completed NCT NCT06492330

    Efficacy and Safety of CS0159 Combined With Semaglutide in MASH Patients With Obesity and T2DM

    Not yet reported Shanghai Jiao Tong University School of Medicine 62 participants Est. completion 2025-04-22 1 site
    MASHType 2 diabetes Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT06497049

    Open Randomized Study of Comparative Pharmacokinetics and Biosimilarity of GP40221 (GEROPHARM LLC, Russia) and Ozempic®.

    Not yet reported Geropharm 120 participants Est. completion 2024-05-05 1 site
    Other conditions: Pharmacokinetics, Safety Issues, Bioequivalence
    View official trial listing →
  • Completed NCT NCT06500143

    Residual Gastric Content After Holding of Glucagon-like Peptide-1 Receptor Agonists Before Elective Surgery

    Ciusss de L'Est de l'Île de Montréal 94 participants Est. completion 2025-02-28 1 site
    Other conditions: Gastric Retention
    View official trial listing →
  • Completed NCT NCT06500429

    A Study to Evaluate the Safety and Efficacy of NG101 in Adult Participants Receiving a Glucagon-like Peptide-1 (GLP-1) Agonist

    Not yet reported Neurogastrx, Inc. 120 participants Est. completion 2024-09-13 1 site Stand-alone
    Other conditions: Overweight and Obesity, Healthy
    View official trial listing →
  • Completed NCT NCT06507475

    Real World Effectiveness of Oral Semaglutide in Thailand Participants With Type 2 Diabetes

    Novo Nordisk A/S 209 participants Est. completion 2024-12-20 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT06533527

    Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy

    Not yet reported The Cleveland Clinic 69 participants Est. completion 2025-05-20 2 sites
    Type 2 diabetes Other conditions: Obesity, Gastroparesis
    View official trial listing →
  • Completed NCT NCT06534411

    A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or Both

    Not yet reported Novo Nordisk A/S 1023 participants Est. completion 2026-07-09 163 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Status unknown NCT NCT06541509

    Mechanisms of Semaglutide Therapy in Heart Failure Patients

    Not yet reported, Not yet reported University Medical Centre Ljubljana 10 participants Est. completion 2025-09-01 3 sites Stand-alone
    Heart failure Other conditions: Obesity
    View official trial listing →
  • Status unknown NCT NCT06557811

    Effect of Oral Semaglutide on Epicardial and Pericoronary Adipose Tissues in Type 2 Diabetes After Myocardial Infarction

    Not yet reported University of Sao Paulo General Hospital 88 participants Est. completion 2026-09-01 1 site
    Cardiovascular disease Other conditions: Diabetic Patients
    View official trial listing →
  • Active, not recruiting NCT NCT06571383

    STEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight Loss

    Not yet reported Novo Nordisk A/S 500 participants Est. completion 2031-11-15 93 sites
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT06579105

    Efficacy, Safety, and Tolerability of Once Daily Oral Administration of AZD5004 Versus Placebo for 26 Weeks in Adults With Type 2 Diabetes Mellitus.

    Not yet reported AstraZeneca 406 participants Est. completion 2025-12-19 97 sites
    Type 2 diabetes
    View official trial listing →
  • Enrolling by invitation NCT NCT06581120

    GLP_1 RA Ultrasound Study

    Children's Hospital Medical Center, Cincinnati 100 participants Est. completion 2026-07 1 site
    Other conditions: Glucagon Like Peptide-1 (GLP-1, Delayed Gastric Emptying, Risk of Aspiration, Diabetes, Morbid Obesity
    View official trial listing →
  • Completed NCT NCT06584916

    A Study of Orforglipron for the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-MAINTAIN)

    Not yet reported Eli Lilly and Company 376 participants Est. completion 2025-11-21 29 sites
    Other conditions: Obesity, Overweight
    View official trial listing →
  • Completed NCT NCT06604624

    Semaglutide in Treatment of Obesity

    Not yet reported CSPC Baike (Shandong) Biopharmaceutical Co., Ltd. 462 participants Est. completion 2025-09-24 1 site
    Other conditions: Weight Management
    View official trial listing →
  • Completed NCT NCT06608433

    Glucagon-like Peptide-1 Receptor Agnoists for the Assessment of Adrenal Function

    Not yet reported University Hospital, Basel, Switzerland 22 participants Est. completion 2025-11-30 1 site Stand-alone
    Other conditions: Healthy Volunteer Study, HPA, Cortisol Deficiency, Adrenal Insufficiency
    View official trial listing →
  • Not yet recruiting NCT NCT06616961

    Efficacy and Safety of Semaglutide for Weight Loss in Overweight or Obese Adults in Bangladesh With or Without Type 2 Diabetes Mellitus

    Not yet reported Popular Medical College Hospital 480 participants Est. completion 2026-10 1 site Stand-alone
    Type 2 diabetes Other conditions: Obesity
    View official trial listing →
  • Withdrawn NCT NCT06619015

    Tailoring Obesity Treatment Trial

    Not yet reported, Not yet reported Esbjerg Hospital - University Hospital of Southern Denmark Est. completion 2025-04-01 1 site Stand-alone
    Prediabetes Other conditions: Obesity, Appetite Regulation
    View official trial listing →
  • Completed NCT NCT06629688

    Semaglutide and Intestinal Iron Absorption

    Not yet reported University Hospital Dubrava 51 participants Est. completion 2024-04-01 1 site Stand-alone
    Type 2 diabetes Other conditions: Iron Absorption
    View official trial listing →
  • Completed NCT NCT06634927

    Pharmacokinetic Similarity, Safety, and Immunogenicity of Semaglutide Injection and Ozempic ® Injection in Healthy Subjects.

    Not yet reported Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. 68 participants Est. completion 2025-02-12 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT06640972

    Effects of RDX-002 on Postprandial Triglycerides in Patients Discontinuing GLP-1 Agonists

    Not yet reported Response Pharmaceuticals 68 participants Est. completion 2025-05-13 1 site
    Other conditions: Triglycerides, Weight Gain Trajectory, Cholesterol, Elevated
    View official trial listing →
  • Completed NCT NCT06642584

    A Research Study Looking at New Protein-based Tablets in Healthy Men - Oral Formulation IV

    Not yet reported Novo Nordisk A/S 90 participants Est. completion 2025-08-13 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT06649344

    A Study of HRS9531 Versus Semaglutide Once Weekly as Add-on Therapy to Metformin Monotherapy or in Combination With SGLT2 Inhibitors in Participants With Type 2 Diabetes

    Not yet reported Fujian Shengdi Pharmaceutical Co., Ltd. 884 participants Est. completion 2026-07-18 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT06659679

    Emulating the PIONEER6 Diabetes Trial Using Healthcare Claims

    Brigham and Women's Hospital 26126 participants Est. completion 2025-03-06 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT06659718

    Emulation of the SOUL Diabetes Trial in Healthcare Claims

    Brigham and Women's Hospital 43650 participants Est. completion 2025-02-13 1 site
    Type 2 diabetes
    View official trial listing →
  • Active, not recruiting NCT NCT06691243

    Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV

    Not yet reported University of Maryland, Baltimore 40 participants Est. completion 2027-07 2 sites Stand-alone
    Other conditions: Cocaine Use Disorder, HIV
    View official trial listing →
  • Completed NCT NCT06699329

    A Study of Enlicitide Decanoate (MK-0616) and Semaglutide in Healthy Adult Participants (MK-0616-023)

    Not yet reported Merck Sharp & Dohme LLC 38 participants Est. completion 2024-05-24 1 site Stand-alone
    Other conditions: Healthy
    View official trial listing →
  • Active, not recruiting NCT NCT06715514

    Menopausal Hormone Therapy, GLP-1 Agonists, and Glucose and Energy Homeostasis in Postmenopausal Women With Diabetes

    Not yet reported Lia Bally 96 participants Est. completion 2026-12-31 1 site
    Type 2 diabetes Other conditions: Menopause
    View official trial listing →
  • Completed NCT NCT06716307

    A Research Study to Compare Blood Levels of Cagrilintide and Semaglutide After Single Doses of Different Versions of Injectable CagriSema in Adults With Overweight or Obesity

    Not yet reported Novo Nordisk A/S 18 participants Est. completion 2025-03-28 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Not yet recruiting NCT NCT06738979

    A Clinical Study Comparing Semaglutide Injection and Wegovy® for Weight Management in Obese Subjects

    Not yet reported Chia Tai Tianqing Pharmaceutical Group Co., Ltd. 408 participants Est. completion 2026-08 66 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Active, not recruiting NCT NCT06754163

    Evaluating the Effect of the STEP@STAH Semaglutide Protocol on the Physical Health Measures of Atypical Antipsychotic-Treated Patients

    Not yet reported St Andrew's Healthcare 20 participants Est. completion 2027-12-30 1 site
    Other conditions: Obesity and Obesity-related Medical Conditions, Psychiatric Disorders
    View official trial listing →
  • Completed NCT NCT06761703

    A Study to Determine the Feasibility of Online Recruitment of People Using an Anti-Obesity Medication for Weight Loss

    Amgen 200 participants Est. completion 2025-01-06 1 site
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT06762314

    Efficacy and Safety of Empagliflozin or Semaglutide in Overweight/Obese Patients With Type 1 Diabetes

    Not yet reported Mostafa Bahaa 114 participants Est. completion 2026-01-20 1 site
    Other conditions: Diabetes
    View official trial listing →
  • Not yet recruiting NCT NCT06764056

    Characterization and Management of Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)

    Not yet reported Institut universitaire de cardiologie et de pneumologie de Québec, University Laval 120 participants Est. completion 2026-05 1 site
    MASH Other conditions: Metabolic Associated Fatty Liver Disease, Obesity
    View official trial listing →
  • Active, not recruiting NCT NCT06778967

    A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Type 2 Diabetes Mellitus

    Not yet reported Gan & Lee Pharmaceuticals. 1100 participants Est. completion 2026-12-11 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT06779929

    Comparative Study of Tirzepatide Versus Dulaglutide (SURPASS CVOT) or Semaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes

    Brigham and Women's Hospital 70000 participants Est. completion 2026-03-01 1 site
    Type 2 diabetes
    View official trial listing →
  • Active, not recruiting NCT NCT06780449

    A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Obesity

    Not yet reported Novo Nordisk A/S 400 participants Est. completion 2028-10-31 36 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Not yet recruiting NCT NCT06788626

    Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke After Endovascular Treatment

    Not yet reported Wei Hu 390 participants Est. completion 2028-02 1 site Stand-alone
    Cardiovascular disease Other conditions: Large Vessel Occlusion, Neuroprotective Drugs, Endovascular Treatment
    View official trial listing →
  • Completed NCT NCT06797869

    A Research Study to Investigate the Effects of CagriSema Compared to Placebo in People With Type 2 Diabetes and Painful Diabetic Peripheral Neuropathy

    Not yet reported Novo Nordisk A/S 142 participants Est. completion 2026-08-05 55 sites Stand-alone
    Type 2 diabetes Other conditions: Diabetic Peripheral Neuropathy
    View official trial listing →
  • Active, not recruiting NCT NCT06801015

    Effects of Long-Acting GLP-1 (Glucagon-like Peptide-1) or Dual Incretin (GLP-1 and GIP [Glucose-dependent Insulinotropic Peptide]) Modulation on Gastric Motor Functions

    Not yet reported Mayo Clinic 30 participants Est. completion 2028-03-31 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Active, not recruiting NCT NCT06803888

    Bariatric Surgery vs. Semaglutide vs. Tirzepatide

    Not yet reported Ali Aminian 140 participants Est. completion 2027-12-01 1 site
    Other conditions: Obesity and Obesity-related Medical Conditions
    View official trial listing →
  • Completed NCT NCT06804603

    A Study to Measure the Effects of Using Tradipitant on Nausea and Vomiting After GLP-1R Agonist Use

    Not yet reported Vanda Pharmaceuticals 124 participants Est. completion 2025-10-06 3 sites
    Other conditions: Obesity
    View official trial listing →
  • Active, not recruiting NCT NCT06807970

    Optimization of Obesity for Total Knee Replacement With Glucagon-like Peptide-1 Receptor Agonist

    Not yet reported The University of Hong Kong 54 participants Est. completion 2028-07-01 1 site
    Osteoarthritis
    View official trial listing →
  • Active, not recruiting NCT NCT06814938

    A Study of a Novel Precision Medicine Approach For Obesity

    Not yet reported Mayo Clinic 135 participants Est. completion 2028-11 2 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT06820047

    Sleeve Gastrectomy vs. Lifestyle & Medications: Impact on BMI Trajectory and Target Attainment in a Matched Cohort Study

    University of Roma La Sapienza 190 participants Est. completion 2024-07-01 2 sites
    Other conditions: Obesity and Obesity-related Medical Conditions
    View official trial listing →
  • Not yet recruiting NCT NCT06825793

    Semaglutide's Weight Loss Effects in Obesity

    Not yet reported Beijing Chao Yang Hospital 56 participants Est. completion 2027-12-31
    Other conditions: Obesity
    View official trial listing →
  • Active, not recruiting NCT NCT06827002

    Effect of Aqueous Extracts of Cissus Quadrangularis and Dichrostachys Glomerata on GLP-1 Concentration and DPP-4 Activity in Overweight and Obese Adults

    Not yet reported, Not yet reported University of Yaounde 1 248 participants Est. completion 2026-08 1 site
    Other conditions: Obesity and Overweight, Appetite Regulation
    View official trial listing →
  • Completed NCT NCT06851962

    Impact of Pharmacogenetic-Guided Treatment on Type 2 Diabetes.

    Not yet reported Fundación para la Investigación del Hospital Clínico de Valencia 92 participants Est. completion 2026-06-30 3 sites Added to GLP-1
    Type 2 diabetes
    View official trial listing →
  • Not yet recruiting NCT NCT06856928

    Impact of Antiobesity Medications on Appetite and Appetite-related Hormones and Metabolites.

    University of Colorado, Denver 16 participants Est. completion 2027-12
    Other conditions: Obesity; Drug
    View official trial listing →
  • Completed NCT NCT06874751

    Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity in the Real World

    Novo Nordisk A/S 45456 participants Est. completion 2025-03-28 1 site Stand-alone
    Cardiovascular disease Other conditions: Overweight, Obesity
    View official trial listing →
  • Active, not recruiting NCT NCT06884293

    A Study Comparing IBI362 vs Semaglutide in Chinese Overweight or Obese Adults With Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD)

    Not yet reported Innovent Biologics (Suzhou) Co. Ltd. 479 participants Est. completion 2027-06-30 1 site
    Other conditions: Overweight, Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD)
    View official trial listing →
  • Not yet recruiting NCT NCT06909006

    Semaglutide Treatment in Type 1 Diabetes

    Not yet reported Nordsjaellands Hospital 122 participants Est. completion 2028-06 1 site
    Other conditions: Obesity in Diabetes, Obesity/Therapy, Type 1 Diabetes Mellitus (T1DM), Insulin Sensitivity/Resistance, Semaglutide, Lipidomics, Metabolomics, Weight Loss, Glycemic Control for Diabetes Mellitus
    View official trial listing →
  • Not yet recruiting NCT NCT06913023

    Semaglutide for the Prevention Of Post-Transplant Diabetes Mellitus

    Not yet reported, Not yet reported University Health Network, Toronto 74 participants Est. completion 2027-11-30 2 sites Stand-alone
    Other conditions: Kidney Transplant Recipient
    View official trial listing →
  • Completed NCT NCT06914102

    Emulation of the STEP-HFpEF DM Heart Failure Trial in Healthcare Claims Data

    Brigham and Women's Hospital 58387 participants Est. completion 2025-06-01 1 site
    Type 2 diabetesHeart failure
    View official trial listing →
  • Completed NCT NCT06914141

    Comparative Effectiveness of Tirzepatide Versus Semaglutide in Individuals With Heart Failure With Preserved Ejection Fraction

    Brigham and Women's Hospital 28118 participants Est. completion 2025-06-01 1 site
    Type 2 diabetesHeart failure
    View official trial listing →
  • Not yet recruiting NCT NCT06946628

    New Triple Therapy in Newly Diagnosed Type 2 Diabetes

    Not yet reported Sun Yat-sen University 296 participants Est. completion 2030-12-31 1 site Stand-alone
    Other conditions: Diabetes Mellitus
    View official trial listing →
  • Not yet recruiting NCT NCT06950684

    Impact of Protein Supplementation and Resistance Training on Body Composition, Functional Parameters, Metabolic Adaptation, and Nitrogen Balance in Adults Aged 45 Years and Older With Overweight or Obesity Receiving Incretin-based Medications

    Not yet reported Assuta Medical Center 180 participants Est. completion 2028-07-01
    Other conditions: Obesity, Overweight (BMI > 25), Weight Loss
    View official trial listing →
  • Enrolling by invitation NCT NCT06954090

    Urinary Proteomics to Guide Early Intervention to Prevent Complications in Type 2 Diabetes - a Feasibility Study

    Not yet reported Steno Diabetes Center Copenhagen 50 participants Est. completion 2027-05-31 1 site
    Chronic kidney disease Other conditions: Type 2 DM, Albuminuria
    View official trial listing →
  • Completed NCT NCT06972992

    A Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASC47 in Combination With Semaglutide

    Not yet reported Ascletis Pharma (China) Co., Limited 28 participants Est. completion 2025-09-22 1 site Stand-alone
    Other conditions: Chronic Weight Management
    View official trial listing →
  • Completed NCT NCT06974825

    A Study of BGM0504 in Chinese Patients With Type 2 Diabetes

    Not yet reported BrightGene Bio-Medical Technology Co., Ltd. 67 participants Est. completion 2024-08-13 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Not yet recruiting NCT NCT06977438

    GLP-1 Plus Lifestyle for Overall Wellness: Find Your Way Forward

    Not yet reported University of Minnesota 1020 participants Est. completion 2032-01-31 1 site Stand-alone
    Other conditions: Obesity, Childhood
    View official trial listing →
  • Active, not recruiting NCT NCT06980623

    Comparative Effectiveness of Tirzepatide vs Semaglutide in Participants With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction

    Brigham and Women's Hospital 26000 participants Est. completion 2026-10-01 1 site
    Type 2 diabetesHeart failure
    View official trial listing →
  • Active, not recruiting NCT NCT06982859

    A Study to Evaluate the Effect of Retatrutide on Insulin Secretion and Insulin Sensitivity in Adult Participants With Type 2 Diabetes Mellitus

    Not yet reported Eli Lilly and Company 95 participants Est. completion 2026-12 1 site
    Other conditions: Diabetes Mellitus, Insulin Sensitivity
    View official trial listing →
  • Active, not recruiting NCT NCT06983171

    Semaglutide Effectiveness in Patients With Metabolic Dysfunction-Associated Fatty Liver Disease in the Real World Practice

    Center of target therapy 70 participants Est. completion 2028-09-12 1 site
    Other conditions: MAFLD
    View official trial listing →
  • Not yet recruiting NCT NCT06987669

    Gastric Emptying in Healthy Volunteers and GLP-1 Agonist Users

    Clinica Alemana de Santiago 155 participants Est. completion 2027-12-31
    Other conditions: Diabetes Type 2, Obesity and Overweight
    View official trial listing →
  • Active, not recruiting NCT NCT07011667

    A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-term

    Not yet reported Novo Nordisk A/S 609 participants Est. completion 2028-10-17 46 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Enrolling by invitation NCT NCT07018544

    A Multicentre, Prospective, Single-arm, Non-interventional Regulatory Post-marketing Surveillance (rPMS) Study to Investigate the Safety and Effectiveness of Wegovy® (Semaglutide) in Patients With Obesity and Patients With Overweight in Routine Clinical Practice in Korea

    Novo Nordisk A/S 840 participants Est. completion 2027-02-28 8 sites
    Other conditions: Obesity and Overweight
    View official trial listing →
  • Not yet recruiting NCT NCT07021937

    Brain Plasticity and GLP-1 Receptor Agonist Treatment for Obesity

    Not yet reported University of Colorado, Denver 120 participants Est. completion 2031-04-30 1 site
    Other conditions: Obesity/Therapy
    View official trial listing →
  • Not yet recruiting NCT NCT07027969

    Metabolic Surgery for Atrial Fibrillation Elimination

    Not yet reported Ali Aminian 100 participants Est. completion 2030-03-31 1 site
    Other conditions: Atrial Fibrillation, Obesity and Obesity-related Medical Conditions
    View official trial listing →
  • Not yet recruiting NCT NCT07035704

    Prevent and Reverse Obesity in Children, Adolescents and Young Adults

    Not yet reported piero portincasa 200 participants Est. completion 2027-03-30 1 site
    Other conditions: Overweight (BMI > 25)
    View official trial listing →
  • Enrolling by invitation NCT NCT07041983

    24-h Energy Expenditure and Anti-obesity Medication

    University of Pisa 30 participants Est. completion 2026-12-01 1 site
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT07043361

    Efficacy of Semaglutide in Glycemic Control, Weight Loss, and Improving Lipidogram- Role of Baseline Vitamin D Levels

    Hillel Yaffe Medical Center 5300 participants Est. completion 2025-04-30 1 site
    Other conditions: Metabolic Disease
    View official trial listing →
  • Not yet recruiting NCT NCT07046273

    Phase III Clinical Study on the Efficacy and Safety of Semaglutide and Ozempic® in Patients With Type 2 Diabetes

    Not yet reported Shandong New Time Pharmaceutical Co., LTD 496 participants Est. completion 2029-02-01
    Type 2 diabetes
    View official trial listing →
  • Enrolling by invitation NCT NCT07055607

    A Two-year Prospective, Observational Study of Wegovy in Real-world Clinical Practice

    Novo Nordisk A/S 1250 participants Est. completion 2028-08-15 30 sites
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT07056803

    Oral vs. Subcutaneous Semaglutide in Type 2 Diabetes Mellitus

    University of Palermo 212 participants Est. completion 2025-06-25 1 site
    Type 2 diabetes
    View official trial listing →
  • Enrolling by invitation NCT NCT07057310

    Aging Well: Targeting Obesity With GLP-1 Agonists to Enhance Physical and Vascular Health in Postmenopausal Women

    Not yet reported Mayo Clinic 30 participants Est. completion 2027-03-31 1 site
    Other conditions: Obesity, Menopause
    View official trial listing →
  • Not yet recruiting NCT NCT07073053

    The Role of Glucagon-Like Peptide-1 Receptor Agonists in Coronary Artery Diseases and Their Potential Mechanisms

    Not yet reported Taipei Veterans General Hospital, Taiwan 60 participants Est. completion 2028-07-31 1 site Stand-alone
    Type 2 diabetes Other conditions: Glucagon-Like Peptide-1 Receptor Agonists, Coronary Arterial Disease (CAD)
    View official trial listing →
  • Active, not recruiting NCT NCT07073417

    A Study to Compare XW003 Injection and Semaglutide Injection in Chinese Adults With Obesity (SLIMMER-UP-SWITCH)

    Not yet reported Hangzhou Sciwind Biosciences Co., Ltd. 163 participants Est. completion 2027-08-23 1 site
    Other conditions: Obesity, Weight Management
    View official trial listing →
  • Terminated NCT NCT07081178

    A Non-interventional Study Investigating Semaglutide in Combination With Lifestyle-based Modifications for the Management of Obesity in Real-World Clinical Practice in Germany (WeGo Real Germany).

    Novo Nordisk A/S 100 participants Est. completion 2025-12-18 1 site
    Other conditions: Obesity
    View official trial listing →
  • Active, not recruiting NCT NCT07087795

    A Study to See the Effect of NNC0194-0499 Alone or in Combination With Semaglutide on Blood Sugar Control in People Living With Type 1 Diabetes

    Not yet reported Novo Nordisk A/S 96 participants Est. completion 2026-09-25 1 site Stand-alone
    Other conditions: Diabetes Mellitus, Type 1
    View official trial listing →
  • Not yet recruiting NCT NCT07090343

    Semaglutide in Patients Undergoing Transcatether Aortic Valve Replacement

    Not yet reported Leiden University Medical Center 826 participants Est. completion 2031-04-01
    Heart failure Other conditions: Aortic Stenosis
    View official trial listing →
  • Enrolling by invitation NCT NCT07092605

    Effectiveness of Microdosed GLP-1 in Improving Health, Quality of Life, and Longevity Measures

    Not yet reported AgelessRx 150 participants Est. completion 2025-12-01 1 site
    Other conditions: Longevity, Quality of Life, Mood, Inflammation, Immune Health, Pain Management, Weight Management, Alertness
    View official trial listing →
  • Completed NCT NCT07096063

    Comparative Effectiveness of Tirzepatide and Semaglutide in Individuals at Cardiovascular Risk

    Brigham and Women's Hospital 887132 participants Est. completion 2025-07-15 1 site
    Type 2 diabetes Other conditions: Overweight, Cardiovascular (CV) Risk
    View official trial listing →
  • Completed NCT NCT07096739

    Tolerance of a High Protein Nutrition Shake in Individuals on GLP-1

    Not yet reported Kate Farms Inc 20 participants Est. completion 2025-09-19 1 site
    Other conditions: GLP-1 Concentration
    View official trial listing →
  • Active, not recruiting NCT NCT07112872

    A Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 Diabetes

    Not yet reported Hoffmann-La Roche 240 participants Est. completion 2026-11-27 50 sites
    Type 2 diabetes
    View official trial listing →
  • Active, not recruiting NCT NCT07115069

    Comparison of Body Composition Changes With Weight Loss Interventions

    Vanderbilt University Medical Center 60 participants Est. completion 2027-12 1 site
    Other conditions: Obesity
    View official trial listing →
  • Not yet recruiting NCT NCT07135245

    Improved Treatment and Monitoring of Alzheimer's Disease

    Not yet reported Rune Skovgaard Rasmussen 180 participants Est. completion 2031-09-30 Stand-alone
    Other conditions: Alzheimer Disease (AD)
    View official trial listing →
  • Not yet recruiting NCT NCT07139548

    A Study of RAY1225 Versus Semaglutide as Add-on Therapy to Oral Antidiabetic Drugs in Participants With Type 2 Diabetes

    Not yet reported Guangdong Raynovent Biotech Co., Ltd 600 participants Est. completion 2026-12-31 1 site
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT07141914

    A Master Protocol for Semaglutide Effects on Cardiovascular and Obesity-related Outcomes in People With Overweight or Obesity in the Real World

    Novo Nordisk A/S 285327 participants Est. completion 2025-12-19 1 site
    Heart failureCardiovascular disease Other conditions: Overweight, Obesity, Primary Prevention
    View official trial listing →
  • Not yet recruiting NCT NCT07152756

    Impact of a One-Week Discontinuation of Semaglutide on Gastric Retention and Endoscopic Mucosal Visibility Scores

    Fudan University 418 participants Est. completion 2028-09-15 1 site
    Other conditions: Gastric Retention
    View official trial listing →
  • Enrolling by invitation NCT NCT07154238

    Characteristics and Treatment Experiences of Individuals Using Injectable Semaglutide for Weight Management, a Cross-sectional Time-series Analysis, Multi-country Study.

    Novo Nordisk A/S 2546 participants Est. completion 2026-09-30 1 site
    Other conditions: Obesity
    View official trial listing →
  • Not yet recruiting NCT NCT07156331

    Research on Effects of Drugs on Body Composition and Function With Imaging in Diabetes

    Kristin Clemens 20 participants Est. completion 2027-12-31
    Type 2 diabetes
    View official trial listing →
  • Not yet recruiting NCT NCT07156591

    Impact of Neuropathy on the Risk of Semaglutide-Induced Gastric Retention

    Fudan University 460 participants Est. completion 2028-09-15 1 site
    Other conditions: Gastric Retention
    View official trial listing →
  • Completed NCT NCT07163624

    UBT251 Injection Phase II (Type 2 Diabetes Mellitus) Study

    Not yet reported The United Bio-Technology (Hengqin) Co., Ltd. 211 participants Est. completion 2025-12-30 1 site
    Type 2 diabetes
    View official trial listing →
  • Not yet recruiting NCT NCT07165158

    The Effect of Semaglutide on Bone Health

    Not yet reported The First Affiliated Hospital of Xiamen University 150 participants Est. completion 2026-12-31 1 site Stand-alone
    Type 2 diabetes Other conditions: Osteoporosis, Osteoporosis Fracture
    View official trial listing →
  • Withdrawn NCT NCT07172867

    A Ph2 Study to Evaluate the Safety, Efficacy and Tolerability of HT-6184 and Semaglutide in Obese Participants With T2DM

    Not yet reported Halia Therapeutics, Inc. Est. completion 2026-01-23 1 site
    Type 2 diabetes Other conditions: Obesity
    View official trial listing →
  • Not yet recruiting NCT NCT07179120

    Can Fat-Burning Shots Boost Fertility? Comparing Weight-Loss Injections vs. Healthy Habits for Obese Men With Low Sperm Health

    Not yet reported First Affiliated Hospital of Wenzhou Medical University 180 participants Est. completion 2027-01-02 Stand-alone
    Other conditions: Obesity-related Male Infertility
    View official trial listing →
  • Active, not recruiting NCT NCT07184086

    A Study to See How Metabolism is Influenced by Weight Loss Due to Intervention With Cagrilintide and Semaglutide Compared to Diet

    Not yet reported Novo Nordisk A/S 80 participants Est. completion 2028-02-09 2 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Not yet recruiting NCT NCT07187856

    Phase 2 Randomized Study of PG-102 vs Placebo and Semaglutide in Type 2 Diabetes Mellitus

    Not yet reported ProGen. Co., Ltd. 80 participants Est. completion 2026-12 1 site
    Type 2 diabetes
    View official trial listing →
  • Active, not recruiting NCT NCT07188545

    Using Secondary Data to Evaluate Sex-based Heterogeneity of GLP-1 Agonists and SGLT2 Inhibitors on Cardiovascular-Kidney-Metabolic Health (CKMH) Outcomes in Real-world Settings (DASH-CKMH)

    Ohio State University 23280000 participants Est. completion 2029-06-30 1 site
    Metabolic syndrome
    View official trial listing →
  • Completed NCT NCT07190144

    Coronary Flow Reserve Changes After Semaglutide Treatment

    Ekrem Bilal Karaayvaz 122 participants Est. completion 2025-08-01 1 site
    Other conditions: The Study Focused on the Vascular Effects of Semaglutide in Both Diabetic and Non-diabetic Patients, Obesity &Amp; Overweight
    View official trial listing →
  • Not yet recruiting NCT NCT07200622

    Oral Semaglutide in Patients With Alzheimer's Disease

    Not yet reported Imperial College London 60 participants Est. completion 2028-12-31
    Other conditions: Alzheimer Disease
    View official trial listing →
  • Completed NCT NCT07216651

    WeDosify Real World Evidence (RWE) Study: Personalized Semaglutide Dosing in U.S. Adults

    Closed Loop Medicine 20 participants Est. completion 2026-03-18 1 site
    Other conditions: Obesity & Overweight
    View official trial listing →
  • Active, not recruiting NCT NCT07220629

    Study to Explore the Safety and Efficacy of NT-0796 as an Adjunct to Semaglutide in Participants With Obesity (RESOLVE-2)

    Not yet reported NodThera Limited 82 participants Est. completion 2026-08-21 9 sites
    Other conditions: Obesity
    View official trial listing →
  • Not yet recruiting NCT NCT07249554

    Combination Therapy for Alcohol Use Disorder

    Not yet reported Johns Hopkins University 45 participants Est. completion 2028-09 1 site
    Alcohol use disorder
    View official trial listing →
  • Not yet recruiting NCT NCT07251556

    GLP-1 Receptor Agonists in Non-diabetic Patients With Psoriatic Arthritis

    Not yet reported Chinese University of Hong Kong 40 participants Est. completion 2027-01-01
    Other conditions: Psoriasis Arthritis
    View official trial listing →
  • Completed NCT NCT07271251

    A Research Study to See if Two Different Formulations of Oral Semaglutide Are Equally Safe and Effective in Reducing the Blood Sugar Level in Japanese People With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 267 participants Est. completion 2026-08-04 15 sites
    Type 2 diabetes
    View official trial listing →
  • Not yet recruiting NCT NCT07276763

    Impact of Discontinuing GLP-1 Receptor Agonists for Two Weeks Prior to Upper Endoscopy on the Risk of Gastric Retention

    Fudan University 16509 participants Est. completion 2025-12-15 1 site
    Other conditions: Gastric Retention
    View official trial listing →
  • Enrolling by invitation NCT NCT07280221

    WEgovy Real World Assessment of Weight Loss in Korea

    Novo Nordisk A/S 500 participants Est. completion 2027-10-31 1 site
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT07280403

    Effect of a Low-carbohydrate Diet on Weight Loss in People Using the Injectable GLP-1 Agonist Semaglutide for Weight Loss

    Not yet reported INQUIS Clinical Research 60 participants Est. completion 2025-11-30 1 site
    Other conditions: Weight Loss
    View official trial listing →
  • Completed NCT NCT07281196

    Semaglutide Effects on Sleep Apnea in Patients With Type 2 Diabetes/Obesity and Comorbid Obstructive Sleep Apnea

    Shanghai Fengxian District Central Hospital 15 participants Est. completion 2026-01-31 1 site
    Obstructive sleep apnea
    View official trial listing →
  • Not yet recruiting NCT NCT07282769

    Semaglutide (Wegovy) Treatment for Trichotillomania

    Not yet reported University of Chicago 10 participants Est. completion 2027-02
    Other conditions: Trichotillomania (Hair-Pulling Disorder), Trichotillomania, Hair Pulling Disorder, Hair Pulling, Hair-Pulling Disorder
    View official trial listing →
  • Active, not recruiting NCT NCT07285902

    A Study Comparing the Efficacy and Safety of HRS9531 Injection With Semaglutide Injection in Subjects With Obesity

    Not yet reported Fujian Shengdi Pharmaceutical Co., Ltd. 572 participants Est. completion 2027-03 2 sites
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT07297238

    Effect of GLP-1 on Intestinal Barrier Function in SBS-IF Patients: A Preliminary Exploration.

    Not yet reported Jinling Hospital, China 20 participants Est. completion 2026-06-30 2 sites Stand-alone
    Other conditions: Short Bowel Syndrome (SBS), Intestinal Failure
    View official trial listing →
  • Not yet recruiting NCT NCT07319975

    Effect of Semaglutide and Tirzepatide Combined With Exercise in Obesity

    Not yet reported Istanbul Galata University 48 participants Est. completion 2026-12 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Not yet recruiting NCT NCT07323134

    The Effect of Semaglutide on the Intestinal Flora in Obesity

    Beijing Chao Yang Hospital 40 participants Est. completion 2026-08-01
    Other conditions: Obesity
    View official trial listing →
  • Active, not recruiting NCT NCT07325435

    Beta Cell Function in Type 2 Diabetes: Differential Effects of SGLT2 Inhibitors and GLIP-Receptor Agonists

    Not yet reported MaryAnn Banerji 60 participants Est. completion 2028-06-30 1 site
    Type 2 diabetes
    View official trial listing →
  • Withdrawn NCT NCT07357740

    A Research Study to Compare Two Different Versions of Injectable CagriSema in People With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S Est. completion 2027-10-13 61 sites
    Type 2 diabetes
    View official trial listing →
  • Withdrawn NCT NCT07357766

    A Research Study to Compare Different Versions of Injectable CagriSema and Placebo in People With Excess Body Weight

    Not yet reported Novo Nordisk A/S Est. completion 2028-01-17 116 sites Stand-alone
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT07368855

    GLP-1 Medicines and Mental Health Changes

    Not yet reported University of California, San Diego 90 participants Est. completion 2025-07-01 1 site
    Other conditions: Obesity, Depression, GLP-1
    View official trial listing →
  • Not yet recruiting NCT NCT07382388

    A Real-World Study on the Impact of Weight Loss on Treatment Efficacy in Overweight/Obese Patients With Plaque Psoriasis

    Peking University Third Hospital 70 participants Est. completion 2027-12-31
    Other conditions: Psoriasis
    View official trial listing →
  • Not yet recruiting NCT NCT07389941

    Semaglutide PrIor to CathEeter Ablation in Patients With Atrial Fibrillation

    Not yet reported University of Luebeck 240 participants Est. completion 2029-04 Stand-alone
    Other conditions: Atrial Fibrillation (AF)
    View official trial listing →
  • Active, not recruiting NCT NCT07390110

    Comparative Effectiveness of Oral Semaglutide vs Sitagliptin Among Individuals With Heart Failure With Preserved Ejection Fraction (STEP-HFpEF DM ORAL)

    Brigham and Women's Hospital 25664 participants Est. completion 2026-06-30 1 site
    Type 2 diabetesHeart failure
    View official trial listing →
  • Not yet recruiting NCT NCT07391267

    Pathogenesis of Chronic Kidney Disease Associated With Metabolic Dysfunction- Associated Fatty Liver Disease (MAFLD) and Treatment Response of Oral Semaglutide.

    Not yet reported Institute of Liver and Biliary Sciences, India 90 participants Est. completion 2028-12-31 1 site
    Chronic kidney disease Other conditions: MAFLD
    View official trial listing →
  • Not yet recruiting NCT NCT07392151

    Reversal to Normoglycemia by Treating Prediabetes

    Not yet reported Michael Mæng 158 participants Est. completion 2029-10 1 site
    Prediabetes Other conditions: Chronic Coronary Syndrome
    View official trial listing →
  • Not yet recruiting NCT NCT07400107

    AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight

    Not yet reported Novo Nordisk A/S 1000 participants Est. completion 2029-01-26 120 sites Stand-alone
    Type 2 diabetes Other conditions: Obesity, Overweight
    View official trial listing →
  • Not yet recruiting NCT NCT07411378

    Testing the Efficacy, Safety, and PK of 20E in Patients With Obesity Who Are Starting Treatment With the GLP-1 Agonist Semaglutide for Weight Loss.

    Not yet reported Biophytis 164 participants Est. completion 2027-08 Stand-alone
    Other conditions: Muscle Wasting, Obesity & Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT07417618

    INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without ASCVD (INTERCEPT-ASCVD)

    Brigham and Women's Hospital 60000 participants Est. completion 2026-06-19 1 site
    Type 2 diabetesCardiovascular disease Other conditions: Overweight
    View official trial listing →
  • Not yet recruiting NCT NCT07423481

    Weight Trajectories and Predictive Factors After Semaglutide in Patients With Grade 3 and Complicated Obesity

    Nantes University Hospital 3000 participants Est. completion 2027-03-01 1 site
    Other conditions: Obesity & Overweight
    View official trial listing →
  • Not yet recruiting NCT NCT07424430

    Real-world Canadian Retrospective Study Evaluating Longitudinal Semaglutide Use on Cardio-Kidney-Metabolic Outcomes

    LMC Diabetes & Endocrinology Ltd. 400 participants Est. completion 2026-05
    Type 2 diabetes Other conditions: Diabetes (DM), Obesity (Disorder)
    View official trial listing →
  • Not yet recruiting NCT NCT07430059

    Safety, Tolerability and Pharmacokinetics of a Subcutaneous Semaglutide Implant

    Not yet reported Vivani Medical, Inc 20 participants Est. completion 2027-01 Stand-alone
    Other conditions: Obesity & Overweight
    View official trial listing →
  • Not yet recruiting NCT NCT07430332

    GLP-1 RA for Stage 1 Type 1 Diabetes

    Not yet reported Children's Hospital Medical Center, Cincinnati 15 participants Est. completion 2030-01-01 1 site Stand-alone
    Other conditions: Stage 1 Diabetes Mellitus, Type 1
    View official trial listing →
  • Not yet recruiting NCT NCT07444073

    Assessing Biological Aging in a Real-World Medical Weight Loss Program Using the LinAge2 Clinical Clock

    National University of Singapore 440 participants Est. completion 2027-12-31 2 sites
    Other conditions: Aging, Obesity & Overweight
    View official trial listing →
  • Enrolling by invitation NCT NCT07456774

    A Two-armed Real-world Study of Ozempic (OW Semaglutide) to Evaluate Its Adherence and Persistence Compared With Other Anti-diabetic Drugs Among Adult T2DM Patients in China

    Novo Nordisk A/S 100000 participants Est. completion 2026-08-31 1 site
    Type 2 diabetes
    View official trial listing →
  • Active, not recruiting NCT NCT07457424

    Direct Measurement of Microstructure of Ingestive Behaviour After Initiation of GLP-1 Receptor Agonist Treatment at Maximum Dose (DIGRAT)

    University College Dublin 140 participants Est. completion 2027-01-31 1 site
    Other conditions: Metabolic Disease, Obesity & Overweight
    View official trial listing →
  • Not yet recruiting NCT NCT07462663

    SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer

    Not yet reported Hospital Universitari de Bellvitge 80 participants Est. completion 2035-01
    Other conditions: Endometrial Cancer, Endometrial Cancer Stage I, Atypical Endometrial Hyperplasia and Endometrial Carcinoma Stage I, Atypical Endometrial Hyperplasia, Endometrial Intraepithelial Neoplasia, Obesity & Overweight, BMI>40, Obesity, Obesity Grade III
    View official trial listing →
  • Not yet recruiting NCT NCT07478653

    MODERN-Dental: Pediatric Obesity, Cardiometabolic Risks, And Periodontal Disease

    Not yet reported Oelisoa Andriankaja 50 participants Est. completion 2028-07-31 1 site
    Other conditions: Obesity, Dental Care for Children
    View official trial listing →
  • Not yet recruiting NCT NCT07483801

    DECODE - Haemodynamic Effects Of Semaglutide and Tirzepatide - a Series of Pilot Studies

    Not yet reported Cambridge University Hospitals NHS Foundation Trust 112 participants Est. completion 2028-04 1 site Mixed
    Cardiovascular disease
    View official trial listing →
  • Active, not recruiting NCT NCT07505303

    MIST (Metabolic Intervention With Semaglutide and THR-β Therapy) Trial

    Not yet reported Eccogene 151 participants Est. completion 2026-10-15 15 sites Stand-alone
    Other conditions: Adult Obesity, Weight Management
    View official trial listing →
  • Not yet recruiting NCT NCT07509112

    Semaglutide for Treatment of People With Methamphetamine Use Disorder: the SHIFT Study

    Not yet reported Kirby Institute 40 participants Est. completion 2027-03 5 sites Stand-alone
    Other conditions: Methamphetamine Use Disorder
    View official trial listing →
  • Not yet recruiting NCT NCT07511543

    Glucagon-like Peptide-1 Receptor Agonists for Endovascular Stroke Thrombectomy

    Not yet reported Population Health Research Institute 826 participants Est. completion 2031-12-30 Stand-alone
    Cardiovascular disease
    View official trial listing →
  • Completed NCT NCT07539584

    Adiponectin in Patients With Metabolic Disorders

    Not yet reported Moscow Regional Research and Clinical Institute (MONIKI) 130 participants Est. completion 2024-04-08 1 site Stand-alone
    Type 2 diabetes Other conditions: Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD)
    View official trial listing →
  • Not yet recruiting NCT NCT07547878

    Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD)

    Not yet reported Baylor Research Institute 64 participants Est. completion 2029-03-31 1 site
    Chronic kidney diseaseType 2 diabetes
    View official trial listing →
  • Not yet recruiting NCT NCT07554417

    Combatting Muscle Loss in Obese Adult Patients on GLP-1 Medications Through Dietary Counseling and Exercise During Treatment Evaluates Whether a 12-week Exercise and Individualized Nutrition Program Can Reduce Muscle and Bone Loss and Improve Strength, Fitness, and Function in Obese Adults on GLP-1

    Not yet reported William Marsh Rice University 20 participants Est. completion 2026-08-06 1 site Stand-alone
    Other conditions: GLP - 1, Obesity & Overweight, Muscle Loss, Exercise Intervention, Dietary Assessment
    View official trial listing →
  • Not yet recruiting NCT NCT07588984

    GLP-1 Medication & Behavioral Health Programs on Weight & Metabolic Outcomes: FLOURISH and THRIVE Prospective Cohort Study

    Noom Inc. 2310 participants Est. completion 2029-05 1 site
    Cardiovascular disease Other conditions: Obesity & Overweight, Weight Loss, Preventative Health, Body Weight
    View official trial listing →
  • Not yet recruiting NCT NCT07592546

    Translational Health Research Into Vascular and Neurocognitive Effects of Weight Loss

    Not yet reported Alain Dagher 240 participants Est. completion 2030-06-01 1 site Stand-alone
    Other conditions: Class I/II Obesity
    View official trial listing →
  • Not yet recruiting NCT NCT07599046

    Fecal Microbiota Transplantation (FMT) Combined With Calorie-Restricted Diet and Semaglutide in Patients With Obesity and Type 2 Diabetes

    Not yet reported Eighth Affiliated Hospital, Sun Yat-sen University 20 participants Est. completion 2029-12-30 1 site Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT07610174

    Effects of Dapagliflozin, Semaglutide, and Their Combination in Heart Failure Patients With Prosthetic Heart Valves

    Not yet reported Kafrelsheikh University 160 participants Est. completion 2026-04-29 1 site Stand-alone
    Heart failure Other conditions: Heart Valve Prosthesis
    View official trial listing →
  • Not yet recruiting NCT NCT07613437

    GLP-1 Receptor Agonist in Primary Intracerebral Hemorrhage: A Phase 2 Randomized Trial

    Not yet reported Chinese University of Hong Kong 200 participants Est. completion 2028-12-31 3 sites
    Other conditions: Intracerebral Hemorrhage
    View official trial listing →
  • Not yet recruiting NCT NCT07614412

    SHIELD-T1D: Shingrix and GLP-1 Agonist for Beta-Cell Preservation in Recent-Onset Type 1 Diabetes.

    Not yet reported Ministry of Health, Saudi Arabia 240 participants Est. completion 2028-12-31 1 site
    Other conditions: Type 1 Diabetes Mellitus
    View official trial listing →
  • Not yet recruiting NCT NCT07617155

    GLP-1 Agonists for Prevention of Recurrent Hypertriglyceridemic Acute Pancreatitis

    Not yet reported Peking Union Medical College Hospital 396 participants Est. completion 2028-12 1 site Stand-alone
    Other conditions: Hypertriglyceridemia Induced Acute Pancreatitis, Recurrent Acute Pancreatitis, Pancreatitis Relapsing, Hypertriglyceridemia
    View official trial listing →
  • Completed NCT NCT07619495

    Injectable Semaglutide vs Dulaglutide in Individuals at Cardiovascular Risk

    Brigham and Women's Hospital 120000 participants Est. completion 2026-06-01 1 site
    Type 2 diabetes Other conditions: Obesity, Overweight
    View official trial listing →
  • Completed NCT NCT07619508

    Tirzepatide vs Semaglutide in Individuals at Cardiovascular Risk But Without Diabetes.

    Brigham and Women's Hospital 100000 participants Est. completion 2026-06-01 1 site
    Other conditions: Obesity, Overweight
    View official trial listing →
  • Not yet recruiting NCT NCT07621640

    Brown Adipose Tissue as a Mechanistic Determinant of Semaglutide Treatment Response in Obesity (BAT-Sema Study)

    Not yet reported Hallym University 80 participants Est. completion 2031-02 2 sites Stand-alone
    Metabolic syndrome Other conditions: Obesity, Brown Adipose Tissue
    View official trial listing →
  • Not yet recruiting NCT NCT07622810

    BALANCE-OBS: Bofanglutide (GZR18) Versus Semaglutide in Latin American Adults With Overweight or Obesity

    Not yet reported Carnot Laboratories 352 participants Est. completion 2027-12 6 sites
    Other conditions: Obesity & Overweight
    View official trial listing →
  • Completed NCT NCT07627074

    Weight Loss in Adults Using Semaglutide (Real-world Study)

    Novo Nordisk A/S 237211 participants Est. completion 2026-06-15 2 sites
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Not yet recruiting NCT NCT07627191

    GLP-1 RA Plus SOC Treatment in First-line, Metastatic Pancreatic, Colorectal, or Hepatocellular Cancer

    Not yet reported University of Arizona 30 participants Est. completion 2028-06-30 1 site Stand-alone
    Other conditions: Pancreatic Cancer, Colorectal Cancer, Hepatocellular Carcinoma
    View official trial listing →
  • Not yet recruiting NCT NCT07628985

    BALANCE-DM2 Study of Bofanglutide in Adults With Type 2 Diabetes

    Not yet reported Carnot Laboratories 374 participants Est. completion 2027-10 7 sites
    Type 2 diabetes
    View official trial listing →
  • Not yet recruiting NCT NCT07642635

    Glucagon-Like Peptide-1 Receptor Agonists to Attenuate Metabolic Risk in Individuals With Duchenne Muscular Dystrophy

    Not yet reported, Not yet reported Vanderbilt University Medical Center 30 participants Est. completion 2030-12 1 site Stand-alone
    Other conditions: Duchenne Muscular Dystrophy (DMD)
    View official trial listing →
  • Active, not recruiting NCT NCT07649759

    Mindfulness-Based Nutrition Group Therapy as an Adjunct to GLP-1 Treatment of Obesity

    Not yet reported Bern University of Applied Sciences 40 participants Est. completion 2027-08 1 site
    Other conditions: Obesity & Overweight, Emotional Eating Behaviour, Mindful Eating Intervention
    View official trial listing →
  • Not yet recruiting NCT NCT07653477

    Phase III Study of UBT251 Injection in Patients With Type 2 Diabetes With Inadequate Glycemic Control on Metformin ± Sulfonylurea/SGLT2 Inhibitor Therapy (UNIGUIDE-2)

    Not yet reported The United Bio-Technology (Hengqin) Co., Ltd. 956 participants Est. completion 2028-02-29
    Type 2 diabetes
    View official trial listing →
  • Not yet recruiting NCT NCT07668414

    A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide

    Not yet reported Novo Nordisk A/S 650 participants Est. completion 2028-10-10 43 sites Stand-alone
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Not yet recruiting NCT NCT07668765

    GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid Obesity

    Gazi University 100 participants Est. completion 2027-05 1 site
    Other conditions: Morbid Obesity, Anorectal Diseases, Drug-Related Side Effects and Adverse Reactions, Constipation, Diarrhea
    View official trial listing →
  • Completed NCT NCT07677865

    GLP-1 Receptor Agonists and Alzheimer's Disease: A Multi-National Target Trial Emulation

    West China Hospital 213891 participants Est. completion 2026-06-24 1 site
    Type 2 diabetes Other conditions: Alzheimer Disease, Obesity & Overweight
    View official trial listing →
  • Enrolling by invitation NCT NCT07677995

    Free Fatty Acid Effects In Type 2 Diabetes

    Not yet reported University of Ulster 60 participants Est. completion 2027-02 1 site Stand-alone
    Type 2 diabetesCardiovascular disease Other conditions: Omega-3 Fatty Acids
    View official trial listing →
  • Not yet recruiting NCT NCT07695454

    Imaging in Semaglutide Study

    The Cleveland Clinic 10 participants Est. completion 2027-06-01 1 site
    Type 2 diabetes Other conditions: BMI Greater Than 30
    View official trial listing →
  • Not yet recruiting NCT NCT07711548

    Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity?

    Not yet reported Knut Mai 292 participants Est. completion 2030-04
    Other conditions: Obesity & Overweight, Weight Loss Maintenance
    View official trial listing →
  • Not yet recruiting NCT NCT07713992

    Efficacy and Safety of Mazdutide in Patients With Type 2 Diabetes Mellitus and Moderate to Severe Nonalcoholic Fatty Liver Disease Previously Treated With Semaglutide

    Not yet reported Tianjin Medical University 72 participants Est. completion 2028-02-01
    Type 2 diabetesMASLD
    View official trial listing →
  • Not yet recruiting NCT NCT07720466

    Salivary Function and Dental Changes During GLP-1 Therapy

    Bilecik Seyh Edebali Universitesi 40 participants Est. completion 2027-03-17 1 site
    Other conditions: Obesity, Dental Erosion, Saliva Collection, Saliva Altered
    View official trial listing →
  • Not yet recruiting NCT NCT07727473

    Preoperative Semaglutide Prior to Radical Prostatectomy

    Not yet reported Banner Health 20 participants Est. completion 2029-05 1 site Stand-alone
    Other conditions: Prostate Cancer
    View official trial listing →
  • Not yet recruiting NCT NCT07728812

    Pragmatic Trial to Study the Cost-Effectiveness of MyPhenome-RX Test to Guide Anti-Obesity Pharmacotherapy

    Not yet reported Phenomix Sciences 424 participants Est. completion 2029-01-01 Stand-alone
    Other conditions: Obesity & Overweight
    View official trial listing →
  • Not yet recruiting NCT NCT07731256

    Semaglutide for Low Back Pain

    Not yet reported Washington University School of Medicine 250 participants Est. completion 2031-09-01 2 sites
    Other conditions: Lower Back Pain, Obesity (BMI>30), Chronic Lower Back Pain, glp1 Agonist
    View official trial listing →
  • Not yet recruiting NCT NCT07737522

    Myocardial Metabolic Flux in Pulmonary Arterial Hypertension

    Not yet reported Imperial College London 32 participants Est. completion 2029-04-01
    Other conditions: Pulmonary Arterial Hypertension
    View official trial listing →
  • Not yet recruiting NCT NCT07754045

    Evaluating the Efficacy and Safety of LUM-201 Plus Semaglutide Versus Semaglutide Plus Placebo in Older Obese Adults

    Not yet reported Lumos Pharma 202 participants Est. completion 2028-02-15 Stand-alone
    Other conditions: Obesity & Overweight
    View official trial listing →
  • Not yet recruiting NCT NCT07755085

    GLP-1s in Hip and Knee Arthroplasty

    Not yet reported Nova Scotia Health Authority 100 participants Est. completion 2028-12 1 site
    Other conditions: Arthritis, Obesity & Overweight, GLP - 1
    View official trial listing →
  • Not yet recruiting NCT NCT07760532

    Comparing Facial Aging Between Identical Twins With 3D Imaging

    Ponsky Facial Aesthetics And Plastic Surgery, Llc 200 participants Est. completion 2026-09 1 site
    Other conditions: Facial Skin Aging, Facial Volume Loss, Wrinkle Appearance
    View official trial listing →
  • Not yet recruiting NCT NCT07760948

    HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide

    Not yet reported Vanderbilt University Medical Center 90 participants Est. completion 2030-11 1 site Stand-alone
    Type 2 diabetes Other conditions: Sarcopenia, Obesity, Muscle Loss, Older Adults
    View official trial listing →
  • Not yet recruiting NCT NCT07769047

    Semaglutide and Structured Lifestyle Support to Improve Heart and Blood Vessel Health in Postmenopausal Obese Breast Cancer Survivors Taking Aromatase Inhibitors

    Not yet reported Mayo Clinic 50 participants Est. completion 2035-07-30 1 site
    Other conditions: Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8
    View official trial listing →
  • Not yet recruiting NCT NCT07770152

    Semaglutide in Youth With Autism Spectrum Disorder

    Not yet reported Children's Hospital Medical Center, Cincinnati 42 participants Est. completion 2029-09-01 1 site Stand-alone
    Other conditions: Autism Spectrum Disorder, Obesity
    View official trial listing →
  • Not yet recruiting NCT NCT07770282

    Efficacy and Safety of Semaglutide Versus Placebo on Cardiometabolic Profile in Patients With Schizophrenia With Metabolic Syndrome

    Not yet reported All India Institute of Medical Sciences, Bhubaneswar 600 participants Est. completion 2030-12-30 Stand-alone
    Metabolic syndrome Other conditions: Schizophrenia Disorder, Antipsychotic-induced Weight Gain, Cardiovascular Risk, Insulin Resistance
    View official trial listing →
  • Not yet recruiting NCT NCT07772960

    Semaglutide Dose Effects on Metabolic and Stress Hormone, Craving and Alcohol Use Outcomes

    Not yet reported Yale University 90 participants Est. completion 2031-10-31 1 site
    Alcohol use disorder Other conditions: Obesity (BMI Equal to or >30)
    View official trial listing →
  • Not yet recruiting NCT NCT07781371

    A Retrospective Real-World Cohort Study

    Novo Nordisk A/S 100000 participants Est. completion 2026-11-02 1 site
    Type 2 diabetesPrediabetesCardiovascular diseaseMASLDChronic kidney disease Other conditions: Obesity, Dyslipidemia
    View official trial listing →
  • Not yet recruiting NCT NCT07783854

    A Randomized Controlled Study of Dose-tapering Regimen of Semaglutide for Weight-Loss Maintenance in Adults With Overweight or Obesity

    Not yet reported Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 72 participants Est. completion 2029-06-30 Stand-alone
    Other conditions: Obesity & Overweight
    View official trial listing →
  • Not yet recruiting NCT NCT07787936

    GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF Registry

    Miedziowe Centrum Zdrowia SA 150 participants Est. completion 2033-01-01 1 site
    Heart failure Other conditions: Obesity, Pulmonary Hypertension, Iron Deficiency
    View official trial listing →
  • Not yet recruiting NCT NCT07797036

    Postpartum Semaglutide to Reduce Cardiometabolic Risk After Gestational Diabetes

    Not yet reported, Not yet reported University of Massachusetts, Worcester 226 participants Est. completion 2030-12-31 1 site Stand-alone
    Metabolic syndrome Other conditions: Gestational Diabetes Mellitus (GDM)
    View official trial listing →
  • Not yet recruiting NCT NCT07812597

    A Study Evaluating Safety and Tolerability of Switching From Semaglutide to Zovaglutide in Adults With Obesity (HORIZON-SWITCH-SZ)

    Not yet reported Beijing QL Biopharmaceutical Co.,Ltd 210 participants Est. completion 2028-03-24 16 sites
    Other conditions: Obesity
    View official trial listing →
Efficacy history
12.4%

Placebo-adjusted weight loss · 68 weeks

Adults with obesity or overweight, without type 2 diabetes

Trial: STEP 1 (Phase 3)

Source →

Results from different trials are not directly comparable — populations, timepoints, and measurement methods differ between studies.

Safety

Gastrointestinal events were the most common adverse events and the main reason for treatment discontinuation.

Source →
Sources

Also known as: Semaglutide, Wegovy, Ozempic, Rybelsus, Semaglutide (administered by PDS290 pen-injector), Semaglutide (Rybelsus®), Semaglutide (1 Mg Dose), Intervention 2: Semaglutide, Microdose semaglutide, Oral semaglutide, Semaglutide 2.4 mg, Semaglutide Oral Tablet, Semaglutide, 1.0 mg/mL, Semaglutide, 1.34 mg/mL

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