Honesty Is The Best Policy
- Dave Knapp
- Aug 28
- 3 min read
I deleted my last post...
This could lose me a few followers, but I believe honesty is the best policy… Well, it’s more than a childhood platitude, really. Striving for integrity is always at the core of what I do. How I prepare for videos, for my podcast, for bringing you news stories, and yes, even responding to trolls in the comments and my emails.
Photo by Brett Jordan on Unsplash
Today, as I was feeling the stress of losing momentum of the growth I have seen here on substack, I messed up. I took a shortcut with my article on mazdutide. I had been reading through the findings from some of the prominent people I follow for information, and without diving into it too deeply for myself, I slammed together an article quickly (as I had the energy) and it wasn’t good.
First, my apologies. In the chaos and uncertainty of the last couple of days, I have allowed myself to become a slave to fear (if you’ve missed my updates, there has been a lot going on with my health). Operating out of fear firmly grates against who I am, and who I know all good things come from. I have been afraid of what the cardiologist might tell me. I have been afraid of not being able to provide for my family. I have been afraid of not being alive for my family. I have been afraid of losing all I have built with OTP. I have been afraid of the lease I just signed for OTP, and the job I have promised to someone. I’ve simply been afraid of losing everything.
This is not who I am. This is not what I know is true.
This is also not an excuse for taking shortcuts with a community who has put so much trust in me. I know many will tell me to “take it easy”, and I have been. I just wasn’t going to be able to continue to rest well without being up front with you.
Please accept my apologies.
Now the real mazdutide story…
The facts are it’s nausea and vomiting rates were actually very close to semaglutide and tirzepatide. So not profoundly different from what we have come to expect from the current class of obesity meds as my article implied. Though I do expect these numbers to ultimately be better than some of the future meds, like Maritide.
Mazdutide 4mg/6mg
Semaglutide 2.4 mg
Tirzepatide 5mg/10mg/15mg
So there you have it. I took a shortcut today, and this is me correcting it, hoping you will forgive and understand that this was out of character.
There were some interesting stories to be told with the mazdutide data beyond the weight loss, including major metabolic improvements. Like other glucagon agonists in trials (retatrutide and survodutide), mazdutide appears to melt off liver fat. It does this all with only a modest increase in heart beats per minute, which is something often looked at with glucagon agonists as glucagon is a cardiac stimulant.
I’m off to rest. Just wanted to correct the record from today. You can count on me for honesty, even when I screw up.
Raise your hand if you’re not perfect : )
More great stuff coming tomorrow, be on the lookout!
This Substack is reader-supported.
To receive new posts and support my work,
consider becoming a free or paid subscriber.
Comments